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Plumbagin Suppresses Pulmonary Fibrosis Via Inhibition of p300 Histone Acetyltransferase Activity
- Title
- Plumbagin Suppresses Pulmonary Fibrosis Via Inhibition of p300 Histone Acetyltransferase Activity
- Authors
- Lee, Soo Yeon; Kim, Mi Jeong; Jang, Subhin; Lee, Gyeong-Eun; Hwang, Soo-Yeon; Kwon, Youngjoo; Hong, Jung Yeon; Sohn, Myung Hyun; Park, Soo-Yeon; Yoon, Ho-Geun
- Ewha Authors
- 권영주
- SCOPUS Author ID
- 권영주
- Issue Date
- 2020
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- ISSN
- 1096-620X
1557-7600
- Citation
- JOURNAL OF MEDICINAL FOOD vol. 23, no. 6, pp. 633 - 640
- Keywords
- histone acetyltransferase; p300; plumbagin; pulmonary fibrosis
- Publisher
- MARY ANN LIEBERT, INC
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis similar to that of malignancy. The causes of IPF are not clearly known, and there is no effective therapy to date. In this study, the natural compound plumbagin, which was isolated from Plumbago rosea root extract, was screened for p300 inhibitory activity. Plumbagin specifically inhibited the activity of p300 toward histone acetyltransferases. Plumbagin treatment significantly suppressed transforming growth factor-beta-induced profibrotic target-gene expression and proliferation of fibroblast cell lines. Moreover, plumbagin significantly inhibited bleomycin-induced pulmonary fibrosis in mice. Taken together, these data demonstrate the inhibitory effects of plumbagin on lung fibrosis and its promise as a therapeutic agent for IPF.
- DOI
- 10.1089/jmf.2019.4670
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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