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Practice considerations on the use of investigational anti-COVID-19 medications: Dosage, administration and monitoring
- Title
- Practice considerations on the use of investigational anti-COVID-19 medications: Dosage, administration and monitoring
- Authors
- Kang, Ji Eun; Rhie, Sandy Jeong
- Ewha Authors
- 이정연; 강지은
- SCOPUS Author ID
- 이정연; 강지은
- Issue Date
- 2020
- Journal Title
- JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- ISSN
- 0269-4727
1365-2710
- Citation
- JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS vol. 45, no. 5, pp. 1199 - 1205
- Keywords
- COVID-19; investigational medication; SARS-CoV-2; severe acute respiratory syndrome
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- What is known and Objective Understanding investigational medications is important. Many older drugs are being investigated for repurposing against COVID-19. We comment on various drugs currently undergoing such trials to optimize their safe use. Comment We describe medications used during early COVID-19 outbreaks in South Korea, focusing on practice aspects including the method of drug administration, drug formulation, patient-monitoring for adverse reactions and drug interactions informed by our experience during the 2015 outbreak of Middle East respiratory syndrome (MERS). We comment on hydroxychloroquine, chloroquine, lopinavir/ritonavir with zinc supplement, remdesivir, tocilizumab, ciclesonide, niclosamide and high-dose intravenous immunoglobulin (IVIG). What is new and conclusion Effective therapies are urgently needed to manage COVID-19, and existing drugs such as antivirals and antimalarials are under investigation for repurposing to meet this need. This process requires up-to-date drug information to ensure optimum use, particularly safety and efficacy profiles of the medications, until convincing evidence is reported.
- DOI
- 10.1111/jcpt.13199
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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