Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강동민 | - |
dc.date.accessioned | 2020-12-03T16:30:13Z | - |
dc.date.available | 2020-12-03T16:30:13Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.other | OAK-28235 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255555 | - |
dc.description.abstract | The epidermal growth factor receptor (EGFR), a member of ErbB receptor tyrosine kinase (RTK) family, is activated through growth factor-induced reorganization of the actin cytoskeleton and subsequent dimerization. We herein explored the molecular mechanism underlying the suppression of ligand-induced EGFR dimerization by CD99 agonists and its relevance to tumor growth in vivo. Epidermal growth factor (EGF) activated the formation of c-Src/focal adhesion kinase (FAK)-mediated intracellular complex and subsequently induced RhoA-and Rac1-mediated actin remodeling, resulting in EGFR dimerization and endocytosis. In contrast, CD99 agonist facilitated FAK dephosphorylation through the HRAS/ERK/PTPN12 signaling pathway, leading to inhibition of actin cytoskeletal reorganization via inactivation of the RhoA and Rac1 signaling pathways. Moreover, CD99 agonist significantly suppressed tumor growth in a BALB/c mouse model injected with MDA-MB-231 human breast cancer cells. Taken together, these results indicate that CD99-derived agonist ligand inhibits epidermal growth factor (EGF)-induced EGFR dimerization through impairment of cytoskeletal reorganization by PTPN12-dependent c-Src/FAK inactivation, thereby suppressing breast cancer growth. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.subject | Actin cytoskeletal reorganization | - |
dc.subject | Breast cancer | - |
dc.subject | CD99 agonist | - |
dc.subject | EGFR dimerization | - |
dc.subject | Endocytosis | - |
dc.subject | FAK dephosphorylation | - |
dc.subject | PTPN12 | - |
dc.subject | Rac1 | - |
dc.subject | RhoA | - |
dc.subject | Tripeptide | - |
dc.title | CD99–PTPN12 axis suppresses actin cytoskeleton-mediated dimerization of epidermal growth factor receptor | - |
dc.type | Article | - |
dc.relation.issue | 10 | - |
dc.relation.volume | 12 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1 | - |
dc.relation.lastpage | 24 | - |
dc.relation.journaltitle | Cancers | - |
dc.identifier.doi | 10.3390/cancers12102895 | - |
dc.identifier.wosid | WOS:000584192400001 | - |
dc.identifier.scopusid | 2-s2.0-85092396620 | - |
dc.author.google | Lee K.-J. | - |
dc.author.google | Kim Y. | - |
dc.author.google | Kim M.S. | - |
dc.author.google | Ju H.-M. | - |
dc.author.google | Choi B. | - |
dc.author.google | Lee H. | - |
dc.author.google | Jeoung D. | - |
dc.author.google | Moon K.-W. | - |
dc.author.google | Kang D. | - |
dc.author.google | Choi J. | - |
dc.author.google | Yook J.I. | - |
dc.author.google | Hahn J.-H. | - |
dc.contributor.scopusid | 강동민(13103841000) | - |
dc.date.modifydate | 20230210131016 | - |