Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.contributor.author | Madhumita Patel | * |
dc.date.accessioned | 2020-08-24T16:30:23Z | - |
dc.date.available | 2020-08-24T16:30:23Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 2576-6422 | * |
dc.identifier.other | OAK-27709 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255253 | - |
dc.description.abstract | To repair nerve damages, nerve conduits are clinically used. However, when the gap distance is greater than 3 cm, nerve damages remain difficult to repair using current empty nerve conduits. To improve the nerve conduit, a silk nerve conduit (diameter = 5 mm and length = 3 cm) filled with a hydrogel matrix was prepared by injecting a thermogelling aqueous poly(ethylene glycol)-poly(l-alanine) (PEG-PA) solution containing stem cells and neurotropic factors into a silk tube at 37 °C. Successful differentiation of the incorporated stem cells into neuronal cells is a key factor for this system to be used as a nerve conduit. Therefore, neuronal differentiation of the incorporated stem cells in the thermogel-filled conduit system was investigated as a bioactive nerve conduit. The study found that the stem cells exhibited 20 to 60-fold increases in mRNA expression for the neuronal biomarkers of NFM and the glial biomarker of GFAP, in the PEG-PA thermogel-filled silk nerve conduit systems containing neurotropic factors of NGF and BDNF compared to control experiments. This article proved the potential of thermogel as an effective filler of a soft nerve conduit. The PEG-PA thermogel-filled silk conduit system incorporating stem cells and neurotropic factors can be promising as a bioactive nerve conduit system. © 2019 American Chemical Society. | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.subject | growth factor delivery | * |
dc.subject | mesenchymal stem cell | * |
dc.subject | nerve conduit | * |
dc.subject | neuronal differentiation | * |
dc.subject | silk | * |
dc.subject | thermogel | * |
dc.title | Polypeptide Thermogel-Filled Silk Tube as a Bioactive Nerve Conduit | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 2 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1967 | * |
dc.relation.lastpage | 1974 | * |
dc.relation.journaltitle | ACS Applied Bio Materials | * |
dc.identifier.doi | 10.1021/acsabm.9b00026 | * |
dc.identifier.scopusid | 2-s2.0-85067886991 | * |
dc.author.google | Patel M. | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Kwon O.H. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.contributor.scopusid | Madhumita Patel(57217400154) | * |
dc.date.modifydate | 20240311135225 | * |