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Pkconverter: R package to convert the pharmacokinetic parameters

Title
Pkconverter: R package to convert the pharmacokinetic parameters
Authors
Cho H.Lee E.-K.
Ewha Authors
이은경
SCOPUS Author ID
이은경scopus
Issue Date
2019
Journal Title
Translational and Clinical Pharmacology
ISSN
2289-0882JCR Link
Citation
Translational and Clinical Pharmacology vol. 27, no. 2, pp. 73 - 79
Keywords
Pharmacokinetic modelPharmacokinetic parameterPopulation analysisRShiny
Publisher
Korean Society Clinical Pharmacology and Therapeutics
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
Population pharmacokinetic analysis and modeling procedures typically require estimates of both population and individual pharmacokinetic parameters. However, only some of these parameters are contained in models and only parameters in the model can be estimated. In this paper, we introduce a new R package, PKconverter, to calculate pharmacokinetic parameters using the relationships among them. After fitting the model, other parameters can be calculated from the functional relationship among the parameters. PKconverter provides the functions to calculate whole parameters along with a Shiny application for converting the parameters. With this package, it is also possible to calculate the standard errors of the other parameters that are not in the model and estimate individual parameters simultaneously. © 2019 Translational and Clinical Pharmacology.
DOI
10.12793/tcp.2019.27.2.73
Appears in Collections:
자연과학대학 > 통계학전공 > Journal papers
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