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Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats
- Title
- Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats
- Authors
- Kong, Chanho; Shin, Jaewoo; Koh, Chin-Su; Lee, Jihyeon; Yoon, Min-Sik; Cho, Yoon Kyung; Kim, Soonyoung; Jun, Sang Beom; Jung, Hyun Ho; Chang, Jin Woo
- Ewha Authors
- 전상범
- SCOPUS Author ID
- 전상범
- Issue Date
- 2019
- Journal Title
- STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
- ISSN
- 1011-6125
1423-0372
- Citation
- STEREOTACTIC AND FUNCTIONAL NEUROSURGERY vol. 97, no. 1, pp. 1 - 9
- Keywords
- Deep brain stimulation; Intracranial self-stimulation; Medial forebrain bundle; Operant conditioning; Stimulation parameter
- Publisher
- KARGER
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: The medial forebrain bundle (MFB) is involved in the integration of pleasure and reward. Previous studies have used various stimulation parameters for operant conditioning, though the effectiveness of these parameters has not been systematically studied. Objectives: The purpose of the present study was to investigate the optimal MFB stimulation parameters for controlling the conditioned behavior of rats. Methods: We evaluated four factors, including intensity, frequency, pulse duration, and train duration, to determine the effect of each on lever pressure applied by animals. We further compared burst and tonic stimulation in terms of learning and performance abilities. Results: The number of lever presses increased with each factor. Animals in the burst stimulation group exhibited more lever presses. Furthermore, the average speed in the boxed plus maze among burst stimulation group subjects was higher. Conclusion: We determined the optimal parameters for movement control of animals in operant conditioning and locomotor tasks by adjusting various electrical stimulation parameters. Our results reveal that a burst stimulation is more effective than a tonic stimulation for increasing the moving speed and number of lever presses. The use of this stimulation technique also allowed us to minimize the training required to control animal behavior. (C) 2019 S. Karger AG, Basel
- DOI
- 10.1159/000497151
- Appears in Collections:
- 공과대학 > 전자전기공학전공 > Journal papers
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