Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송은주 | * |
dc.date.accessioned | 2020-08-20T16:30:17Z | - |
dc.date.available | 2020-08-20T16:30:17Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1574-7891 | * |
dc.identifier.issn | 1878-0261 | * |
dc.identifier.other | OAK-27636 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255013 | - |
dc.description.abstract | SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor-beta (TGF-beta) signaling through ubiquitin-mediated degradation of TGF-beta receptor I. However, the regulatory mechanism of SMURF2 is largely unknown. In this study, we identified that micro(mi)R-195 and miR-497 putatively target SMURF2 using several target prediction databases. Both miR-195 and miR-497 bind to the 3 '-UTR of the SMURF2 mRNA and inhibit SMURF2 expression. Furthermore, miR-195 and miR-497 regulate SMURF2-dependent T beta RI ubiquitination and cause the activation of the TGF-beta signaling pathway in lung cancer cells. Upregulation of miR-195 and miR-497 significantly reduced cell viability and colony formation through the activation of TGF-beta signaling. Interestingly, miR-195 and miR-497 also reduced the invasion ability of lung cancer cells when cells were treated with TGF-beta 1. Subsequent in vivo studies in xenograft nude mice model revealed that miR-195 and miR-497 repress tumor growth. These findings demonstrate that miR-195 and miR-497 act as a tumor suppressor by suppressing ubiquitination-mediated degradation of TGF-beta receptors through SMURF2, and suggest that miR-195 and miR-497 are potential therapeutic targets for lung cancer. | * |
dc.language | English | * |
dc.publisher | WILEY | * |
dc.subject | lung cancer | * |
dc.subject | miR-195 | * |
dc.subject | miR-497 | * |
dc.subject | SMURF2 | * |
dc.subject | Transforming growth factor (TGF)-beta | * |
dc.title | MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-beta receptor I ubiquitination | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2663 | * |
dc.relation.lastpage | 2678 | * |
dc.relation.journaltitle | MOLECULAR ONCOLOGY | * |
dc.identifier.doi | 10.1002/1878-0261.12581 | * |
dc.identifier.wosid | WOS:000495179400001 | * |
dc.author.google | Chae, Dong-Kyu | * |
dc.author.google | Park, Jinyoung | * |
dc.author.google | Cho, Moonsoo | * |
dc.author.google | Ban, Eunmi | * |
dc.author.google | Jang, Mihue | * |
dc.author.google | Yoo, Young Sook | * |
dc.author.google | Kim, Eunice EunKyeong | * |
dc.author.google | Baik, Ja-Hyun | * |
dc.author.google | Song, Eun Joo | * |
dc.contributor.scopusid | 송은주(7101904210) | * |
dc.date.modifydate | 20240311110828 | * |