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Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation

Title
Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
Authors
Nam K.-W.Kim C.K.Yu S.Chung J.-W.Bang O.Y.Kim G.-M.Jung J.-M.Song T.-J.Kim Y.-J.Kim B.J.Heo S.H.Park K.-Y.Kim J.-M.Park J.-H.Choi J.C.Park M.-S.Kim J.-T.Choi K.-H.Hwang Y.H.Seo W.-K.Oh K.
Ewha Authors
송태진
SCOPUS Author ID
송태진scopus
Issue Date
2020
Journal Title
Scientific Reports
ISSN
2045-2322JCR Link
Citation
Scientific Reports vol. 10, no. 1
Publisher
Nature Research
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association between serum cTnI and early neurological deterioration (END) in patients with AF-related stroke. We included consecutive AF-related stroke patients between 2013 and 2015. END was defined as an increase ≥ 2 in the total NIHSS score or ≥ 1 in the motor NIHSS score within the first 72 h of admission. A total of 1,133 patients with AF-related stroke were evaluated. In multivariable analysis, cTnI [adjusted odds ratio (aOR) = 1.16, 95% confidence interval (CI) 1.00–1.34; P = 0.047] remained significant after adjusting for confounders. Initial NIHSS score (aOR = 1.03, 95% CI 1.00–1.06; P = 0.043) was also positively associated with END; meanwhile, the use of anticoagulants was negatively associated in both vitamin K antagonists (aOR = 0.35, 95% CI 0.23–0.54; P < 0.001) and new oral anticoagulants (aOR = 0.41, 95% CI 0.19–0.89; P = 0.024). In conclusion, higher serum cTnI was associated with END in patients with AF-related stroke. © 2020, The Author(s).
DOI
10.1038/s41598-020-69303-5
Appears in Collections:
의과대학 > 의학과 > Journal papers
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