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Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
- Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation
- Nam K.-W.; Kim C.K.; Yu S.; Chung J.-W.; Bang O.Y.; Kim G.-M.; Jung J.-M.; Song T.-J.; Kim Y.-J.; Kim B.J.; Heo S.H.; Park K.-Y.; Kim J.-M.; Park J.-H.; Choi J.C.; Park M.-S.; Kim J.-T.; Choi K.-H.; Hwang Y.H.; Seo W.-K.; Oh K.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Scientific Reports
- Scientific Reports vol. 10, no. 1
- Nature Research
- SCIE; SCOPUS
- Document Type
- Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association between serum cTnI and early neurological deterioration (END) in patients with AF-related stroke. We included consecutive AF-related stroke patients between 2013 and 2015. END was defined as an increase ≥ 2 in the total NIHSS score or ≥ 1 in the motor NIHSS score within the first 72 h of admission. A total of 1,133 patients with AF-related stroke were evaluated. In multivariable analysis, cTnI [adjusted odds ratio (aOR) = 1.16, 95% confidence interval (CI) 1.00–1.34; P = 0.047] remained significant after adjusting for confounders. Initial NIHSS score (aOR = 1.03, 95% CI 1.00–1.06; P = 0.043) was also positively associated with END; meanwhile, the use of anticoagulants was negatively associated in both vitamin K antagonists (aOR = 0.35, 95% CI 0.23–0.54; P < 0.001) and new oral anticoagulants (aOR = 0.41, 95% CI 0.19–0.89; P = 0.024). In conclusion, higher serum cTnI was associated with END in patients with AF-related stroke. © 2020, The Author(s).
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