Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2020-08-13T16:30:09Z | - |
dc.date.available | 2020-08-13T16:30:09Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 2041-6520 | * |
dc.identifier.issn | 2041-6539 | * |
dc.identifier.other | OAK-27267 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254921 | - |
dc.description.abstract | Theranostics that combines both diagnosis and therapy into a single platform has recently emerged as a promising biomedical approach for cancer treatment; however, the development of efficient theranostic agents with excellent optical properties remains a challenge. Here, we report novel mitochondria-targetingBODIPYphotosensitizers (R-BODs) that possess considerable singlet oxygen generation capabilities and good fluorescence properties for imaging-guided photodynamic therapy (PDT). The incorporation of sulfur atoms into the pi-conjugated skeleton ofBODIPYalong with the introduction of different functional groups at themeso-position of theBODIPYcore is essential for tuning the photophysical and photosensitizing properties. Notably, the MeOPh-substituted thiophene-fusedBODIPY(MeO-BOD, R =p-methoxyphenyl) displayed the highest singlet oxygen generation capability (phi(Delta)approximate to 0.85 in air-saturated acetonitrile) and a moderate fluorescence quantum yield (phi(f)= 17.11). Furthermore,MeO-BODshowed good biocompatibility, low dark toxicity and superior fluorescence imaging properties in living cells. More importantly, the PDT efficacy of mitochondria-specific anchoring ofMeO-BODwas remarkably amplified with an extremely low half-maximal inhibitory concentration (IC50) value of 95 nM. We believe that the incorporation of an electron-donating group at themeso-position of the thiophene-fusedBODIPYplatform may be an effective approach for developing theranostic agents for precision cancer therapy. | * |
dc.language | English | * |
dc.publisher | ROYAL SOC CHEMISTRY | * |
dc.title | Fine-tuning the electronic structure of heavy-atom-freeBODIPYphotosensitizers for fluorescence imaging and mitochondria-targeted photodynamic therapy | * |
dc.type | Article | * |
dc.relation.issue | 25 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 6479 | * |
dc.relation.lastpage | 6484 | * |
dc.relation.journaltitle | CHEMICAL SCIENCE | * |
dc.identifier.doi | 10.1039/d0sc01171a | * |
dc.identifier.wosid | WOS:000544484900011 | * |
dc.identifier.scopusid | 2-s2.0-85087777625 | * |
dc.author.google | Qi, Sujie | * |
dc.author.google | Kwon, Nahyun | * |
dc.author.google | Yim, Yubin | * |
dc.author.google | Van-Nghia Nguyen | * |
dc.author.google | Yoon, Juyoung | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |