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자연과학대학
화학·나노과학전공
Journal papers
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Two-photon imaging of hydrogen polysulfides in living cells and hippocampal tissues
Title
Two-photon imaging of hydrogen polysulfides in living cells and hippocampal tissues
Authors
Chung J.
;
Li H.
;
Lim C.S.
;
Kim H.M.
;
Yoon J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영
Issue Date
2020
Journal Title
Sensors and Actuators, B: Chemical
ISSN
0925-4005
Citation
Sensors and Actuators, B: Chemical vol. 322
Keywords
Cell imaging
;
Fluorescent probe
;
Hydrogen polysulfides
;
Two-photon
Publisher
Elsevier B.V.
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Hydrogen polysulfide (H2Sn) is an emerging topic of research because it plays a critical role in the pathological and physiological activities of an organism. Therefore, visual monitoring of H2Sn activity in living cells is critical. In our work, a two-photon fluorescent probe NI-H2S2 based on a naphthalimide skeleton was developed as a molecular tool for detecting hydrogen polysulfides in solution and live HeLa cells. NI-H2S2 showed rapid response and high sensitivity. Notably, hydrogen polysulfides in hippocampal tissue of mice could also be tracked using the probe under a two-photon fluorescence microscope. Therefore, this probe NI-H2S2 is expected to serve as a pragmatic tool for studying the physiological roles of hydrogen polysulfides in living cells and in vivo. © 2020 Elsevier B.V.
DOI
10.1016/j.snb.2020.128564
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