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Identifying Long-Term Survival Candidates among Patients with Isolated Locoregionally Recurrent Breast Cancer: Implications of the Use of Systemic Chemotherapy
- Title
- Identifying Long-Term Survival Candidates among Patients with Isolated Locoregionally Recurrent Breast Cancer: Implications of the Use of Systemic Chemotherapy
- Authors
- Kim, Byoung Hyuck; Shin, Kyung Hwan; Chie, Eui Kyu; Kim, Jin Ho; Kim, Kyubo; Hwang, Ki-Tae; Kim, Jongjin; Choi, In Sil; Park, Jin Hyun; Kim, Suzy
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2020
- Journal Title
- JOURNAL OF BREAST CANCER
- ISSN
- 1738-6756
2092-9900
- Citation
- JOURNAL OF BREAST CANCER vol. 23, no. 3, pp. 279 - 290
- Keywords
- Breast neoplasm; Neoplasm recurrence; Local; Risk factors; Survivors
- Publisher
- KOREAN BREAST CANCER SOC
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose: We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Methods: We analyzed 125 patients who underwent salvage local treatments for ILRR after initial curative breast surgery. Results: Fifty-two (41.6%) patients experienced secondary recurrence or disease progression, of which 20 (38.5%) experienced a secondary locoregional recurrence and 40 (76.9%) experienced DM as the first site of failure. In multivariate analysis of distant metastasis free survival (DMFS) and post-recurrence OS, the initial pN2-3 stage, a disease-free interval of < 36 months, and non-curative resection for recurrent disease were independently poor prognosticators. The score for patients stratified according to the number of risk factors increased from 0 to 3; the corresponding 5-year DMFS rates were 91.4%, 53.0%, 35.9%, and 0% and the 5-year OS rates were 97.3%, 70.4%, 32.7%, and 25.0%, respectively (p < 0.001). Systemic chemotherapy reduced DM in patients with a score of 2-3, but it did not in those with a score of 0-1. Conclusion: Our collective stratification can help with prognosis prediction for ILRR of breast cancer. Depending on the DM risk of patients, the potential combination of systemic therapy should be discussed further.
- DOI
- 10.4048/jbc.2020.23.e31
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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