Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김규보 | * |
dc.date.accessioned | 2020-07-16T16:30:08Z | - |
dc.date.available | 2020-07-16T16:30:08Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1738-6756 | * |
dc.identifier.issn | 2092-9900 | * |
dc.identifier.other | OAK-27220 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254176 | - |
dc.description.abstract | Purpose: We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Methods: We analyzed 125 patients who underwent salvage local treatments for ILRR after initial curative breast surgery. Results: Fifty-two (41.6%) patients experienced secondary recurrence or disease progression, of which 20 (38.5%) experienced a secondary locoregional recurrence and 40 (76.9%) experienced DM as the first site of failure. In multivariate analysis of distant metastasis free survival (DMFS) and post-recurrence OS, the initial pN2-3 stage, a disease-free interval of < 36 months, and non-curative resection for recurrent disease were independently poor prognosticators. The score for patients stratified according to the number of risk factors increased from 0 to 3; the corresponding 5-year DMFS rates were 91.4%, 53.0%, 35.9%, and 0% and the 5-year OS rates were 97.3%, 70.4%, 32.7%, and 25.0%, respectively (p < 0.001). Systemic chemotherapy reduced DM in patients with a score of 2-3, but it did not in those with a score of 0-1. Conclusion: Our collective stratification can help with prognosis prediction for ILRR of breast cancer. Depending on the DM risk of patients, the potential combination of systemic therapy should be discussed further. | * |
dc.language | English | * |
dc.publisher | KOREAN BREAST CANCER SOC | * |
dc.subject | Breast neoplasm | * |
dc.subject | Neoplasm recurrence | * |
dc.subject | Local | * |
dc.subject | Risk factors | * |
dc.subject | Survivors | * |
dc.title | Identifying Long-Term Survival Candidates among Patients with Isolated Locoregionally Recurrent Breast Cancer: Implications of the Use of Systemic Chemotherapy | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 279 | * |
dc.relation.lastpage | 290 | * |
dc.relation.journaltitle | JOURNAL OF BREAST CANCER | * |
dc.identifier.doi | 10.4048/jbc.2020.23.e31 | * |
dc.identifier.wosid | WOS:000543376900005 | * |
dc.author.google | Kim, Byoung Hyuck | * |
dc.author.google | Shin, Kyung Hwan | * |
dc.author.google | Chie, Eui Kyu | * |
dc.author.google | Kim, Jin Ho | * |
dc.author.google | Kim, Kyubo | * |
dc.author.google | Hwang, Ki-Tae | * |
dc.author.google | Kim, Jongjin | * |
dc.author.google | Choi, In Sil | * |
dc.author.google | Park, Jin Hyun | * |
dc.author.google | Kim, Suzy | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.date.modifydate | 20240222162403 | * |