Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2020-07-10T16:30:16Z | - |
dc.date.available | 2020-07-10T16:30:16Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1433-7851 | * |
dc.identifier.issn | 1521-3773 | * |
dc.identifier.other | OAK-27042 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254138 | - |
dc.description.abstract | Monitoring fluctuations in enzyme overexpression facilitates early tumor detection and excision. An AIEgen probe (DQM-ALP) for the imaging of alkaline phosphatase (ALP) activity was synthesized. The probe consists of a quinoline-malononitrile (QM) core decorated with hydrophilic phosphate groups as ALP-recognition units. The rapid liberation of DQM-OH aggregates in the presence of ALP resulted in aggregation-induced fluorescence. The up-regulation of ALP expression in tumor cells was imaged using DQM-ALP. The probe permeated into 3D cervical and liver tumor spheroids for imaging spatially heterogeneous ALP activity with high spatial resolution on a two-photon microscopy platform, providing the fluorescence-guided recognition of sub-millimeter tumorigenesis. DQM-ALP enabled differentiation between tumor and normal tissue ex vivo and in vivo, suggesting that the probe may serve as a powerful tool to assist surgeons during tumor resection. | * |
dc.language | English | * |
dc.publisher | WILEY-V C H VERLAG GMBH | * |
dc.subject | aggregation-induced emission | * |
dc.subject | AIEgens | * |
dc.subject | enzyme activity | * |
dc.subject | nanoprobes | * |
dc.subject | tumor detection | * |
dc.title | An Activatable AIEgen Probe for High-Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision | * |
dc.type | Article | * |
dc.relation.issue | 25 | * |
dc.relation.volume | 59 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 10186 | * |
dc.relation.lastpage | 10195 | * |
dc.relation.journaltitle | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | * |
dc.identifier.doi | 10.1002/anie.202001675 | * |
dc.identifier.wosid | WOS:000537909700051 | * |
dc.identifier.scopusid | 2-s2.0-85081646467 | * |
dc.author.google | Li, Haidong | * |
dc.author.google | Yao, Qichao | * |
dc.author.google | Xu, Feng | * |
dc.author.google | Li, Yueqing | * |
dc.author.google | Kim, Dayeh | * |
dc.author.google | Chung, Jeewon | * |
dc.author.google | Baek, Gain | * |
dc.author.google | Wu, Xiaofeng | * |
dc.author.google | Hillman, Prima Fitria | * |
dc.author.google | Lee, Eun Young | * |
dc.author.google | Ge, Haoying | * |
dc.author.google | Fan, Jiangli | * |
dc.author.google | Wang, Jingyun | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Peng, Xiaojun | * |
dc.author.google | Yoon, Juyoung | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |