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Airflow limitation as a risk factor for vascular stiffness

Title
Airflow limitation as a risk factor for vascular stiffness
Authors
Sheen S.S.Kim H.J.Singh D.Hwang S.C.Park K.J.Ahn S.V.Lee E.Park B.Jung J.H.Park R.W.Kim J.H.Park H.-S.Park J.H.
Ewha Authors
안성복
Issue Date
2020
Journal Title
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
ISSN
1815-7920JCR Link
Citation
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease vol. 24, no. 6, pp. 577 - 584
Publisher
NLM (Medline)
Indexed
SCOPUS scopus
Document Type
Article
Abstract
BACKGROUND: Cardiovascular disease is one of the main causes of mortality in patients with chronic obstructive pulmonary disease (COPD), and atherosclerosis is a cause of cardiac comorbidities in COPD. However, it is not clear whether airflow limitation is associated with atherosclerosis irrespective of smoking.OBJECTIVE: To investigate whether airflow limitation is independently associated with vascular stiffness.METHODS: We enrolled 18 893 participants (male 70.5%; mean age 47.5 ± 9.8 years; never smokers 44.2%) who underwent spirometry and brachial-ankle pulse wave velocity (baPWV) as part of a standard health examination at Ajou University Hospital, Suwon, South Korea, from January 2010 to December 2015.We defined vascular peripheral atherosclerosis as baPWV ≥ 1400 cm/s and airflow limitation as pre-bronchodilator ratio of forced expiratory volume in 1 sec (FEV1) to forced vital capacity (FVC) <70%.RESULTS: Mean baPWV was higher in subjects with airflow limitation (1477.6 ± 331.7 cm/sec, n = 638) than in those without airflow limitation (1344.1 ± 231.8 cm/sec, n = 18255, P < 0.001). In multivariate logistic regression analysis, the following were independent predictors associated with peripheral atherosclerosis (P < 0.05): age, male sex, fasting serum glucose, mean blood pressure, serum leukocyte count, serum low density lipoprotein level and FEV1.CONCLUSION: Airflow limitation was an independent predictor of vascular stiffness irrespective of smoking history, which suggests that airflow limitation is linked with atherosclerosis.
DOI
10.5588/ijtld.19.0457
Appears in Collections:
신산업융합대학 > 융합보건학과 > Journal papers
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