Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안성복 | * |
dc.date.accessioned | 2020-07-10T16:30:06Z | - |
dc.date.available | 2020-07-10T16:30:06Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1027-3719 | * |
dc.identifier.issn | 1815-7920 | * |
dc.identifier.other | OAK-27113 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254078 | - |
dc.description.abstract | BACKGROUND: Cardiovascular disease is one of the main causes of mortality in patients with chronic obstructive pulmonary disease (COPD), and atherosclerosis is a cause of cardiac comorbidities in COPD. However, it is not clear whether airflow limitation is associated with atherosclerosis irrespective of smoking. OBJECTIVE: To investigate whether airflow limitation is independently associated with vascular stiffness. METHODS: We enrolled 18 893 participants (male 70.5%; mean age 47.5 +/- 9.8 years; never smokers 44.2%) who underwent spirometry and brachial-ankle pulse wave velocity (baPWV) as part of a standard health examination at Ajou University Hospital, Suwon, South Korea, from January 2010 to December 2015. We defined vascular peripheral atherosclerosis as baPWV >= 1400 cm/s and airflow limitation as pre-bronchodilator ratio of forced expiratory volume in 1 sec (FEV1) to forced vital capacity (FVC) >70%. RESULTS: Mean baPWV was higher in subjects with airflow limitation (1477.6 +/- 331.7 cm/sec, n = 638) than in those without airflow limitation (1344.1 +/- 231.8 cm/sec, n = 18255, P < 0.001). In multivariate logistic regression analysis, the following were independent predictors associated with peripheral atherosclerosis (P < 0.05): age, male sex, fasting serum glucose, mean blood pressure, serum leukocyte count, serum low density lipoprotein level and FEV1. CONCLUSION: Airflow limitation was an independent predictor of vascular stiffness irrespective of smoking history, which suggests that airflow limitation is linked with atherosclerosis. | * |
dc.language | English | * |
dc.publisher | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | * |
dc.subject | airflow limitation | * |
dc.subject | atherosclerosis | * |
dc.subject | smoking | * |
dc.title | Airflow limitation as a risk factor for vascular stiffness | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 24 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 577 | * |
dc.relation.lastpage | + | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | * |
dc.identifier.doi | 10.5588/ijtld.19.0457 | * |
dc.identifier.wosid | WOS:000600572300007 | * |
dc.identifier.scopusid | 2-s2.0-85086694780 | * |
dc.author.google | Sheen, S. S. | * |
dc.author.google | Kim, H. J. | * |
dc.author.google | Singh, D. | * |
dc.author.google | Hwang, S. C. | * |
dc.author.google | Park, K. J. | * |
dc.author.google | Ahn, S. V. | * |
dc.author.google | Lee, E. | * |
dc.author.google | Park, B. | * |
dc.author.google | Jung, J. H. | * |
dc.author.google | Park, R. W. | * |
dc.author.google | Kim, J. H. | * |
dc.author.google | Park, H-S. | * |
dc.author.google | Park, J. H. | * |
dc.contributor.scopusid | 안성복(47360986600) | * |
dc.date.modifydate | 20240308130443 | * |