Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오만숙 | - |
dc.date.accessioned | 2020-06-01T16:30:27Z | - |
dc.date.available | 2020-06-01T16:30:27Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | OAK-26907 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253973 | - |
dc.description.abstract | Exposure to environment-polluting chemicals (EPC) is associated with the development of diabetes. Many EPCs exert toxic effects via aryl hydrocarbon receptor (AhR) and/or mitochondrial inhibition. Here we investigated if the levels of human exposure to a mixture of EPC and/or mitochondrial inhibitors could predict the development of diabetes in a prospective study, the Korean Genome and Epidemiological Study (KoGES). We analysed AhR ligands (AhRL) and mitochondria-inhibiting substances (MIS) in serum samples (n = 1,537), collected during the 2008 Ansung KoGES survey with a 4-year-follow-up. Serum AhRL, determined by the AhR-dependent luciferase reporter assay, represents the contamination level of AhR ligand mixture in serum. Serum levels of MIS, analysed indirectly by MIS-ATP or MIS-ROS, are the serum MIS-induced mitochondria inhibiting effects on ATP content or reactive oxygen species (ROS) production in the cultured cells. Among 919 normal subjects at baseline, 7.1% developed impaired glucose tolerance (IGT) and 1.6% diabetes after 4 years. At the baseline, diabetic and IGT sera displayed higher AhRL and MIS than normal sera, which correlated with indices of insulin resistance. When the subjects were classified according to ROC cut-off values, fully adjusted relative risks of diabetes development within 4 years were 7.60 (95% CI, 4.23–13.64), 4.27 (95% CI, 2.38–7.64), and 21.11 (95% CI, 8.46–52.67) for AhRL ≥ 2.70 pM, MIS-ATP ≤ 88.1%, and both, respectively. Gender analysis revealed that male subjects with AhRL ≥ 2.70 pM or MIS-ATP ≤ 88.1% showed higher risk than female subjects. High serum levels of AhRL and/or MIS strongly predict the future development of diabetes, suggesting that the accumulation of AhR ligands and/or mitochondrial inhibitors in body may play an important role in the pathogenesis of diabetes. © 2020, The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Research | - |
dc.title | Serum biomarkers from cell-based assays for AhRL and MIS strongly predicted the future development of diabetes in a large community-based prospective study in Korea | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 10 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Scientific Reports | - |
dc.identifier.doi | 10.1038/s41598-020-62550-6 | - |
dc.identifier.wosid | WOS:000562162800017 | - |
dc.identifier.scopusid | 2-s2.0-85083545009 | - |
dc.author.google | Lee H.K. | - |
dc.author.google | Park W.H. | - |
dc.author.google | Kang Y.C. | - |
dc.author.google | Kang S. | - |
dc.author.google | Im S. | - |
dc.author.google | Park S. | - |
dc.author.google | Kim J.T. | - |
dc.author.google | Lee M. | - |
dc.author.google | Seok J. | - |
dc.author.google | Oh M.-S. | - |
dc.author.google | Choi H.S. | - |
dc.author.google | Pak Y.K. | - |
dc.contributor.scopusid | 오만숙(7201600334) | - |
dc.date.modifydate | 20230411111253 | - |