Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2020-06-01T16:30:25Z | - |
dc.date.available | 2020-06-01T16:30:25Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0024-3205 | * |
dc.identifier.issn | 1879-0631 | * |
dc.identifier.other | OAK-26912 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253968 | - |
dc.description.abstract | Brain oxidative stress and neuroinflammation have been implicated in various psychiatric disorders. The current study investigated the effect and mechanism of 25-Methoxyhispidol A (25-MHA) against CCl4-induced anxiety and depression. Mice were challenged with CCl4 (1 ml/kg; i.p.) after 30 min of 25-MHA (1, 5 and 10 mg/kg; i.p.) administration. Pretreatment with 25-MHA (10 mg/kg) significantly attenuated the anxiety and depression-like behavior in testing models. The oxidative stress induced by CCl4 was significantly attenuated by pretreatment with 25-MHA. The immunohistochemical (IHC) analysis showed a reduction in kelch-like ECH-associated protein 1 (Keap1) and improvement in expression of nuclear factor erythroid-2-related factor (Nrf-2) and heme oxygenase (HO)-1. In addition, 25-MHA significantly attenuated the CCl4-mediated depletion of antioxidant enzymes in hippocampus (HC) and prefrontal cortex (PFC) region and reduced the expression of toll-like receptor (TLR)-4 and nuclear factor kappa B (NF-kappa B), along with a decreased production of pro-inflammatory cytokines in HC and PFC region. Pretreatment with 25-MHA also showed an improved expression of neurotrophic factors i.e., brain derived growth factor (BDNF) and vascular endothelial growth factor (VEGF). Furthermore, 25-MHA inhibited malondialdehyde (MDA) and ammonia level in plasma, liver, HC and PFC regions of mice brain. 25-MHA also exhibited anti-apoptotic effect evident from the reduced expression of caspase-3 and decreased hippocampal DNA damage in comet assay. Furthermore, decreased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and corticosterone level, along with prevention of CCl4-induced alterations in thickness of dentate gyrus and intact hepatic cells morphology, represented by hippocampal and liver histopathology, indicated the neuroprotective effect of 25-MHA. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Anxiety | * |
dc.subject | Depression | * |
dc.subject | 25-MHA | * |
dc.subject | Oxido-nitrasative stress | * |
dc.subject | Apoptosis | * |
dc.subject | Neurotrophic factors | * |
dc.title | Neuroprotective effect of 25-Methoxyhispidol A against CCl4-induced behavioral alterations by targeting VEGF/BDNF and caspase-3 in mice | * |
dc.type | Article | * |
dc.relation.volume | 253 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | LIFE SCIENCES | * |
dc.identifier.doi | 10.1016/j.lfs.2020.117684 | * |
dc.identifier.wosid | WOS:000550277500026 | * |
dc.identifier.scopusid | 2-s2.0-85083650064 | * |
dc.author.google | Shal, Bushra | * |
dc.author.google | Khan, Adnan | * |
dc.author.google | Naveed, Muhammad | * |
dc.author.google | Ali, Hussain | * |
dc.author.google | Seo, Eun Kyoung | * |
dc.author.google | Choi, Hyukjae | * |
dc.author.google | Khan, Salman | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |