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ROS-Sensitive Degradable PEG–PCL–PEG Micellar Thermogel

Title
ROS-Sensitive Degradable PEG–PCL–PEG Micellar Thermogel
Authors
Lee H.J.Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문scopus
Issue Date
2020
Journal Title
Small
ISSN
1613-6810JCR Link
Citation
Small vol. 16, no. 12
Keywords
biodegradationmicellesoxalatereactive oxygen speciesthermogels
Publisher
Wiley-VCH Verlag
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
A reactive oxygen species (ROS)-sensitive degradable polymer would be a promising material in designing a disease-responsive system or accelerating degradation of polymers with slow hydrolysis kinetics. Here, a thermogelling poly(ethylene glycol)–polycaprolactone–poly(ethylene glycol) (PEG–PCL–PEG or EG12–CL20–EG12) triblock copolymer with an oxalate group at the middle of the polymer is reported. The polymers form micelles with an average size of 100 nm in water. Thermogelation is observed in a concentration range of 8.0−37.0 wt%. In particular, the aqueous PEG–PCL–PEG triblock copolymer solutions are in a gel state at 37 °C in a concentration range of 25.0–37.0 wt%, whereas the aqueous PEG–PCL diblock copolymer solutions are in a sol state in the same concentration range at 37 °C. Thus, the gel depot could dissolve out once degradation of the triblock copolymers occurs at the oxalate group as confirmed by the in vitro experiment. In vivo gel formation is confirmed by injecting an aqueous PEG–PCL–PEG solution (36.0 wt%) into the subcutaneous layer of rats. The gel completely disappears in 21 d. A model polypeptide drug (cyclosporine A) is released over 21 d from the in situ formed gel. The micelle-based thermogel of PEG–PCL–PEG with ROS-triggering degradability is a promising injectable material for biomedical applications. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI
10.1002/smll.201903045
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자연과학대학 > 화학·나노과학전공 > Journal papers
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