Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2020-04-13T16:32:27Z | - |
dc.date.available | 2020-04-13T16:32:27Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.issn | 1520-6025 | - |
dc.identifier.other | OAK-26771 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253838 | - |
dc.description.abstract | Tripartilactam (1) is a natural macrocyclic lactam originally reported to have a unique [18,8,4]-tricyclic framework. However, the validity of this structure has been contested since niizalactam C (2), bearing a [18,6,6]-tricyclic skeleton, was proposed as an alternative structure in 2015. In the present study, a comprehensive reinvestigation of NMR spectroscopic data and a C-13-C-13 COSY NMR experiment identified direct C-13-C-13 coupling, thus leading to the unequivocal revision of the structure of tripartilactam as niizalactam C (2). In addition, whole-genome sequencing analysis of the tripartilactam-producing bacterial strain and subsequent bioinformatics and mutagenesis analyses identified its biosynthetic pathway, which probably utilizes one of the type I polyketide synthase (PKS) modules iteratively during its biosynthesis and exhibits spontaneous [4+2] cycloaddition from the precursor compound, sceliphrolactam, in the post-PKS process. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Structure Revision and the Biosynthetic Pathway of Tripartilactam | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 83 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 578 | - |
dc.relation.lastpage | 583 | - |
dc.relation.journaltitle | JOURNAL OF NATURAL PRODUCTS | - |
dc.identifier.doi | 10.1021/acs.jnatprod.9b00819 | - |
dc.identifier.wosid | WOS:000526306000003 | - |
dc.identifier.scopusid | 2-s2.0-85078544438 | - |
dc.author.google | Hwang, Sunghoon | - |
dc.author.google | Kim, Eunji | - |
dc.author.google | Lee, Jeeyeon | - |
dc.author.google | Shin, Jongheon | - |
dc.author.google | Yoon, Yeo Joon | - |
dc.author.google | Oh, Dong-Chan | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210708161345 | - |