Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.contributor.author | 손성근 | * |
dc.contributor.author | 이미니 | * |
dc.contributor.author | 서승운 | * |
dc.contributor.author | 전세진 | * |
dc.date.accessioned | 2020-04-13T16:30:06Z | - |
dc.date.available | 2020-04-13T16:30:06Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 2211-1247 | * |
dc.identifier.other | OAK-26754 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253754 | - |
dc.description.abstract | CD137, a potent costimulatory receptor for CD8(+) T cells, is expressed in various non-T cells, but little is known about its regulatory functions in these cells. In this study, we show that CD137 signaling, specifically in intestinal CD11b(-)CD103(+) dendritic cells (DCs), restricts acute colitis progression. Mechanistically, CD137 engagement activates TAK1 and subsequently stimulates the AMPK-PGC-1 alpha axis to enhance expression of the Aldh1a2 gene encoding the retinoic acid (RA) metabolizing enzyme RALDH2. RA can act on CD11b(+)CD103(-) DCs and induce SOCS3 expression, which, in turn, suppresses p38MAPK activation and interleukin-23 (IL-23) production. Administration of RA in DC-specific CD137(-/-) mice represses IL-23-producing CD11b(+)CD103(-) DCs and TH17 cells, indicating that RA is a major inhibitory effector molecule against intestinal CD11b(+)CD103(-) DCs. Additionally, the therapeutic effect of the anti-CD137 antibody is abrogated in DC-specific CD137(-/-) mice. Taken together, our results define a mechanism of paracrine immunoregulation operating between adjacent DC subsets in the intestine. | * |
dc.language | English | * |
dc.publisher | CELL PRESS | * |
dc.title | CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b(-)CD103(+) DCs | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4124 | * |
dc.relation.lastpage | + | * |
dc.relation.journaltitle | CELL REPORTS | * |
dc.identifier.doi | 10.1016/j.celrep.2020.02.103 | * |
dc.identifier.wosid | WOS:000521989500017 | * |
dc.identifier.scopusid | 2-s2.0-85081996013 | * |
dc.author.google | Jin, Jing | * |
dc.author.google | Jung, In-Hyuk | * |
dc.author.google | Moon, Shin Hye | * |
dc.author.google | Jeon, Sejin | * |
dc.author.google | Jeong, Se-Jin | * |
dc.author.google | Sonn, Seong-Keun | * |
dc.author.google | Seo, Seungwoon | * |
dc.author.google | Lee, Mi-Ni | * |
dc.author.google | Song, Eun Ju | * |
dc.author.google | Kweon, Hyae Yon | * |
dc.author.google | Kim, Sinai | * |
dc.author.google | Kim, Tae Kyeong | * |
dc.author.google | Kim, Juyang | * |
dc.author.google | Cho, Hong Rae | * |
dc.author.google | Choi, Jae-Hoon | * |
dc.author.google | Kwon, Byungsuk | * |
dc.author.google | Oh, Goo Taeg | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.contributor.scopusid | 손성근(8628610900) | * |
dc.contributor.scopusid | 이미니(35285954900;56136972000) | * |
dc.contributor.scopusid | 서승운(56559237000;14013859100) | * |
dc.contributor.scopusid | 전세진(55609439300) | * |
dc.date.modifydate | 20240304133607 | * |