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Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors
- Title
- Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors
- Authors
- Park, Myoung-Soon; Park, Hyun-Ju; An, Young Jae; Choi, Joon Hun; Cha, Geunyoung; Lee, Hwa Jeong; Park, So-Jung; Dewang, Purushottam M.; Kim, Dae-Kee
- Ewha Authors
- 이화정; 김대기
- SCOPUS Author ID
- 이화정; 김대기
- Issue Date
- 2020
- Journal Title
- JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- ISSN
- 1475-6366
1475-6374
- Citation
- JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY vol. 35, no. 1, pp. 702 - 712
- Keywords
- 2; 4-Disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles; ALK5 inhibition; cancer immunotherapeutic agent; docking
- Publisher
- TAYLOR &
FRANCIS LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A series of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles, 7a-c, 11a-h, and 16a-h has been synthesised and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. Incorporation of a quinoxalin-6-yl moiety and a methylene linker at the 4- and 2-position of the imidazole ring, respectively, and a m-CONH2 substituent in the phenyl ring generated a highly potent and selective ALK5 inhibitor 11e. Docking model of ALK5 in complex with 11e showed that it fitted well in the ATP-binding pocket with favourable interactions.
- DOI
- 10.1080/14756366.2020.1734799
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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