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Nano theranostics platforms that utilize proteins

Title
Nano theranostics platforms that utilize proteins
Authors
Lee S.Pham T.C.Bae C.Choi Y.Kim Y.K.Yoon J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2020
Journal Title
Coordination Chemistry Reviews
ISSN
0010-8545JCR Link
Citation
Coordination Chemistry Reviews vol. 412
Keywords
BioimagingDrug deliveryImaging-guided cancer therapyPhototherapyProtein-based theranostics
Publisher
Elsevier B.V.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Proteins have received increasing attention as a novel platform for drug delivery and phototheranostic agents that may serve as new nanomedicines. In drug delivery system, proteins can act as powerful tools with self-assembled structures, triggering groups, receptors and agents to enhance cell penetration. Compared to other nanoparticle based theranostics, nano-platforms for theranostics by utilizing proteins have unique merits, such as higher loading capacities and high efficiency of photosensitizers in phototherapies. However, the full potential of protein-based theranostics has not been achieved thus far. In this review, recent advances made in this area were discussed following a format based on proteins in drug delivery systems, proteins-dye complexes for phototherapy of cancer, proteins nanoparticles for imaging-guided cancer therapy such as fluorescent imaging, positron emission tomography (PET), magnetic resonance imaging (MRI), ultrasound (US) Imaging, PA imaging and proteins-based nanoprobes and nanostructures. Importantly, this discussion also provides a view of future advances that will likely be made in this area and their potential clinical applications. © 2020
DOI
10.1016/j.ccr.2020.213258
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자연과학대학 > 화학·나노과학전공 > Journal papers
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