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A Supramolecular-Based Dual-Wavelength Phototherapeutic Agent with Broad-Spectrum Antimicrobial Activity Against Drug-Resistant Bacteria

Title
A Supramolecular-Based Dual-Wavelength Phototherapeutic Agent with Broad-Spectrum Antimicrobial Activity Against Drug-Resistant Bacteria
Authors
Yu, Zhi-HaoLi, XingshuXu, FuguiHu, Xi-LeYan, JiataoKwon, NahyunChen, Guo-RongTang, TingtingDong, XiaojingMai, YiyongChen, DaijieYoon, JuyoungHe, Xiao-PengTian, He
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2020
Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN
1433-7851JCR Link

1521-3773JCR Link
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION vol. 59, no. 9, pp. 3658 - 3664
Keywords
antimicrobial activitygraphene nanoribbonsphototherapyporphyrinsupramolecular structures
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
With the ever-increasing threat posed by the multi-drug resistance of bacteria, the development of non-antibiotic agents for the broad-spectrum eradication of clinically prevalent superbugs remains a global challenge. Here, we demonstrate the simple supramolecular self-assembly of structurally defined graphene nanoribbons (GNRs) with a cationic porphyrin (Pp4N) to afford unique one-dimensional wire-like GNR superstructures coated with Pp4N nanoparticles. This Pp4N/GNR nanocomposite displays excellent dual-modal properties with significant reactive-oxygen-species (ROS) production (in photodynamic therapy) and temperature elevation (in photothermal therapy) upon light irradiation at 660 and 808 nm, respectively. This combined approach proved synergistic, providing an impressive antimicrobial effect that led to the complete annihilation of a wide spectrum of Gram-positive, Gram-negative, and drug-resistant bacteria both in vitro and in vivo. The study also unveils the promise of GNRs as a new platform to develop dual-modal antimicrobial agents that are able to overcome antibiotic resistance.
DOI
10.1002/anie.201913506
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자연과학대학 > 화학·나노과학전공 > Journal papers
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