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Synthesis of Sub 3 nm-Sized Uniform Magnetite Nanoparticles Using Reverse Micelle Method for Biomedical Application

Title
Synthesis of Sub 3 nm-Sized Uniform Magnetite Nanoparticles Using Reverse Micelle Method for Biomedical Application
Authors
Jung, EuiyoungKim, Sung-WonCho, AhyoungKim, Yu-JinJeong, Gun-JaeKim, JinheungBhang, Suk HoYu, Taekyung
Ewha Authors
김진흥
SCOPUS Author ID
김진흥scopus
Issue Date
2019
Journal Title
MATERIALS
ISSN
1996-1944JCR Link
Citation
MATERIALS vol. 12, no. 23
Keywords
iron oxidemagnetitenanoparticlesreverse micellesub-3 nm
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
We report a synthetic method for small and uniform Fe3O4 (magnetite) nanoparticles under mild conditions. Spherical sub-3 nm-sized magnetite nanoparticles were prepared via reverse micelles composed of oleylamine, F127, xylene, and water for the reaction of iron(III) stearate with hydrazine at a reaction temperature of 90 degrees C in air atmosphere. These synthesized magnetite nanoparticles exhibited good size uniformity. By controlling experimental conditions, we could easily control both size and size uniformity of these magnetite nanoparticles. We further investigated whether Fe3O4 could be used in biomedical applications. Cytotoxicity of Fe3O4 was evaluated with human adipose-derived stem cells (hADSCs). Our results showed that the number of hADSCs did not significantly decrease when these cells were treated with Fe3O4 nanoparticles at a concentration of up to 9 mu g/mL. Apoptotic activity and cell proliferation of hADSCs treated with Fe3O4 nanoparticles were similar to those of hADSCs without any treatment. This novel method could be used for synthesizing uniform and biocompatible Fe3O4 nanoparticles with further biomedical applications.
DOI
10.3390/ma12233850
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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