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Regulation of Autophagy Is a Novel Tumorigenesis-Related Activity of Multifunctional Translationally Controlled Tumor Protein

Title
Regulation of Autophagy Is a Novel Tumorigenesis-Related Activity of Multifunctional Translationally Controlled Tumor Protein
Authors
Lee, Ji-SunJang, Eun-HwaWoo, Hyun AeLee, Kyunglim
Ewha Authors
이경림우현애
SCOPUS Author ID
이경림scopus; 우현애scopus
Issue Date
2020
Journal Title
CELLS
ISSN
2073-4409JCR Link
Citation
CELLS vol. 9, no. 1
Keywords
TCTPcancerautophagy
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Review
Abstract
Translationally controlled tumor protein (TCTP) is highly conserved in eukaryotic organisms and plays multiple roles regulating cellular growth and homeostasis. Because of its anti-apoptotic activity and its role in the regulation of cancer metastasis, TCTP has become a promising target for cancer therapy. Moreover, growing evidence points to its clinical role in cancer prognosis. How TCTP regulates cellular growth in cancer has been widely studied, but how it regulates cellular homeostasis has received relatively little attention. This review discusses how TCTP is related to cancer and its potential as a target in cancer therapeutics, including its novel role in the regulation of autophagy. Regulation of autophagy is essential for cell recycling and scavenging cellular materials to sustain cell survival under the metabolic stress that cancer cells undergo during their aggressive proliferation.
DOI
10.3390/cells9010257
Appears in Collections:
약학대학 > 약학과 > Journal papers
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