Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상혁 | * |
dc.contributor.author | 강상원 | * |
dc.date.accessioned | 2020-02-07T16:30:24Z | - |
dc.date.available | 2020-02-07T16:30:24Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 2213-2317 | * |
dc.identifier.other | OAK-26316 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253365 | - |
dc.description.abstract | Triple-negative breast cancer (TNBC) cells, which do not express genes for estrogen receptor (ER), progesterone receptor (PR), and Her2/neu, develop highly aggressive and metastatic tumors resistant to chemo- and hormonal therapies. We found that expression of glutathione peroxidase-1 (Gpx1) is silenced in the non-TNBC cells but significantly maintained in the TNBC cell lines. Such Gpx1 expression plays a vital role in the metastasis of TNBC cells by regulating cell adhesion. Transcriptomic and signaling pathway analyses demonstrate that depletion of Gpxl essentially impairs cell adhesion/spreading by down-regulating FAK/c-Src activation. Mechanistically, Gpx1 interacts with FAK kinase and prevents the kinase inactivation by H2O2, not lipid hydroperoxide. As a result, depletion of Gpx1 suppresses lung metastasis of TNBC cells in vivo. Overall, our study identifies that Gpx1 is a redox safeguard of FAK kinase and its inhibition may provide an effective way to control the metastasis of deadly malignant TNBC. | * |
dc.language | English | * |
dc.publisher | ELSEVIER | * |
dc.subject | Glutathione peroxidase | * |
dc.subject | Triple-negative breast cancer | * |
dc.subject | Metastasis | * |
dc.subject | Adhesion | * |
dc.subject | Focal adhesion kinase | * |
dc.title | Glutathione peroxidase-1 regulates adhesion and metastasis of triple-negative breast cancer cells via FAK signaling | * |
dc.type | Article | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | REDOX BIOLOGY | * |
dc.identifier.doi | 10.1016/j.redox.2019.101391 | * |
dc.identifier.wosid | WOS:000506181200009 | * |
dc.identifier.scopusid | 2-s2.0-85075919419 | * |
dc.author.google | Lee, Eunkyung | * |
dc.author.google | Choi, Ahyoung | * |
dc.author.google | Jun, Yukyung | * |
dc.author.google | Kim, Namhee | * |
dc.author.google | Yook, Jong In | * |
dc.author.google | Kim, Soo Youl | * |
dc.author.google | Lee, Sanghyuk | * |
dc.author.google | Kang, Sang Won | * |
dc.contributor.scopusid | 이상혁(57212112170) | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.date.modifydate | 20240415122632 | * |