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A 3D-printed polycaprolactone/beta-tricalcium phosphate mandibular prosthesis: A pilot animal study

Title
A 3D-printed polycaprolactone/beta-tricalcium phosphate mandibular prosthesis: A pilot animal study
Authors
Park, Jae HongJung, Soo YeonLee, Chi-KyouBan, Myung JinLee, Sang JinKim, Ha YeongOh, Hyun JuKim, Byeong KookPark, Hae SangJang, Si-HyongKim, Han Su
Ewha Authors
김한수정수연
SCOPUS Author ID
김한수scopus
Issue Date
2020
Journal Title
LARYNGOSCOPE
ISSN
0023-852XJCR Link

1531-4995JCR Link
Citation
LARYNGOSCOPE vol. 130, no. 2, pp. 358 - 366
Keywords
OsteogenesisStem cell3D printingGraft material
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Objective In this study, we assessed the effectiveness of a tonsil-derived mesenchymal stem cell (TMSC)-transplanted polycaprolactone/beta-tricalcium phosphate prosthesis (specifically designed for easier fixing and grafting with a single scaffold) on rabbit mandible osteogenesis. Methods The mandibles of 18 rabbits were exposed, and 10 x 8-mm bone defects were made. Two rabbits did not receive implants; four were reconstructed with the scaffold control (SC) (SC group); four were reconstructed with scaffolds soaked in peripheral blood (PB) (PB group); four were reconstructed with TMSC-transplanted scaffolds (TMSC group); and four were reconstructed with differentiated osteocyte-transplanted scaffolds (DOC) (DOC group). Each rabbit was sacrificed 12 weeks after surgery, and the area of new bone formation was investigated by mechanical testing, histology, and micro-computed tomography. Results More extended and denser new bone masses were observed in the TMSC and DOC groups, although fibrosis and vascular formation levels were similar in all groups, suggesting that the dual-structured scaffold alone provides a good environment for bone attachment and regeneration. The bone volumes of representative scaffolds from the SC, PB, TMSC, and DOC groups were 43.12, 48.35, 53.10, and 57.44% of the total volumes, respectively. Conclusion The design of the scaffold resulted in effective osteogenesis, and TMSCs showed osteogenic potency, indicating that their combination could enable effective bone regeneration. Level of Evidence NA Laryngoscope, 130:358-366, 2020
DOI
10.1002/lary.27908
Appears in Collections:
의과대학 > 의학과 > Journal papers
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