Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김한수 | * |
dc.contributor.author | 정수연 | * |
dc.date.accessioned | 2020-02-07T16:30:15Z | - |
dc.date.available | 2020-02-07T16:30:15Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0023-852X | * |
dc.identifier.other | OAK-26391 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253351 | - |
dc.description.abstract | Objective: In this study, we assessed the effectiveness of a tonsil-derived mesenchymal stem cell (TMSC)-transplanted polycaprolactone/beta-tricalcium phosphate prosthesis (specifically designed for easier fixing and grafting with a single scaffold) on rabbit mandible osteogenesis. Methods: The mandibles of 18 rabbits were exposed, and 10 × 8-mm bone defects were made. Two rabbits did not receive implants; four were reconstructed with the scaffold control (SC) (SC group); four were reconstructed with scaffolds soaked in peripheral blood (PB) (PB group); four were reconstructed with TMSC-transplanted scaffolds (TMSC group); and four were reconstructed with differentiated osteocyte-transplanted scaffolds (DOC) (DOC group). Each rabbit was sacrificed 12 weeks after surgery, and the area of new bone formation was investigated by mechanical testing, histology, and micro-computed tomography. Results: More extended and denser new bone masses were observed in the TMSC and DOC groups, although fibrosis and vascular formation levels were similar in all groups, suggesting that the dual-structured scaffold alone provides a good environment for bone attachment and regeneration. The bone volumes of representative scaffolds from the SC, PB, TMSC, and DOC groups were 43.12, 48.35, 53.10, and 57.44% of the total volumes, respectively. Conclusion: The design of the scaffold resulted in effective osteogenesis, and TMSCs showed osteogenic potency, indicating that their combination could enable effective bone regeneration. Level of Evidence: NA Laryngoscope, 130:358–366, 2020. © 2019 The American Laryngological, Rhinological and Otological Society, Inc. | * |
dc.language | English | * |
dc.publisher | John Wiley and Sons Inc. | * |
dc.subject | 3D printing | * |
dc.subject | Graft material | * |
dc.subject | Osteogenesis | * |
dc.subject | Stem cell | * |
dc.title | A 3D-printed polycaprolactone/β-tricalcium phosphate mandibular prosthesis: A pilot animal study | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 130 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 358 | * |
dc.relation.lastpage | 366 | * |
dc.relation.journaltitle | Laryngoscope | * |
dc.identifier.doi | 10.1002/lary.27908 | * |
dc.identifier.wosid | WOS:000509566900021 | * |
dc.identifier.scopusid | 2-s2.0-85063005366 | * |
dc.author.google | Park J.H. | * |
dc.author.google | Jung S.Y. | * |
dc.author.google | Lee C.-K. | * |
dc.author.google | Ban M.J. | * |
dc.author.google | Lee S.J. | * |
dc.author.google | Kim H.Y. | * |
dc.author.google | Oh H.J. | * |
dc.author.google | Kim B.K. | * |
dc.author.google | Park H.S. | * |
dc.author.google | Jang S.-H. | * |
dc.author.google | Kim H.S. | * |
dc.contributor.scopusid | 김한수(56509934900) | * |
dc.contributor.scopusid | 정수연(57189007888) | * |
dc.date.modifydate | 20240422114059 | * |