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Two-Photon Fluorescence Probe for Selective Monitoring of Superoxide in Live Cells and Tissues

Title
Two-Photon Fluorescence Probe for Selective Monitoring of Superoxide in Live Cells and Tissues
Authors
Chen, LiyanCho, Myoung KiWu, DiHwan Myung KimYoon, Juyoung
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2019
Journal Title
ANALYTICAL CHEMISTRY
ISSN
0003-2700JCR Link

1520-6882JCR Link
Citation
ANALYTICAL CHEMISTRY vol. 91, no. 22, pp. 14691 - 14696
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
The abnormal location or generation of superoxide radical anion (O-2(center dot-)) are implicated in many diseases, including cancers; thus, development of an efficient method to detect O(2)(center dot- )is of great importance. Inspired by the fluorophore-governed selective manner to O-2(center dot-) and peroxynitrite (ONOO-) of previously reported phosphinate-based fluorescence probes, in this contribution, a phosphinothioate-containing probe, TPP, was designed. The probe exhibited easy accessibility through a one-step sequence and good photostability and biocompatibility. Interestingly, TPP showed high specificity and sensitivity to O-2(center dot-) over other reactive oxygen species/nitrogen species including ONOO. Furthermore, with the assistance of two-photon microscopy, TPP was successfully applied for imaging endogenous O-2(center dot-) in live cells and tissues.
DOI
10.1021/acs.analchem.9b03937
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자연과학대학 > 화학·나노과학전공 > Journal papers
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