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Cofactor specificity engineering of a long-chain secondary alcohol dehydrogenase from Micrococcus luteus for redox-neutral biotransformation of fatty acids

Title
Cofactor specificity engineering of a long-chain secondary alcohol dehydrogenase from Micrococcus luteus for redox-neutral biotransformation of fatty acids
Authors
Seo, Eun-JiKim, Hye-JiKim, Myeong-JuKim, Jeong-SunPark, Jin-Byung
Ewha Authors
박진병
SCOPUS Author ID
박진병scopus
Issue Date
2019
Journal Title
CHEMICAL COMMUNICATIONS
ISSN
1359-7345JCR Link

1364-548XJCR Link
Citation
CHEMICAL COMMUNICATIONS vol. 55, no. 96, pp. 14462 - 14465
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
Structure-based engineering of a NAD(+)-dependent secondary alcohol dehydrogenase from Micrococcus luteus led to a 1800-fold increase in catalytic efficiency for NADP(+). Furthermore, the engineered enzymes (e.g., D37S/A38R/V39S/T15I) were successfully coupled to a NADPH-dependent Baeyer-Villiger monooxygenase from Pseudomonas putida KT2440 for redox-neutral biotransformations of C18 fatty acids into C9 chemicals.
DOI
10.1039/c9cc06447h
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
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