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Effects of pharmacist interventions on reducing prescribing errors of investigational drugs in oncology clinical trials

Title
Effects of pharmacist interventions on reducing prescribing errors of investigational drugs in oncology clinical trials
Authors
Moon, Jin YoungLee, YeonhongHan, Ji MinLee, Mi HyungYee, JeongSong, Mi KyungKim, Young JuGwak, Hye Sun
Ewha Authors
곽혜선문진영
SCOPUS Author ID
곽혜선scopus
Issue Date
2020
Journal Title
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
ISSN
1078-1552JCR Link

1477-092XJCR Link
Citation
JOURNAL OF ONCOLOGY PHARMACY PRACTICE vol. 26, no. 1, pp. 29 - 35
Keywords
Pharmacist interventioninvestigational drugsclinical trialsprescribing error
Publisher
SAGE PUBLICATIONS LTD
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Objectives This study aimed to investigate the effectiveness of pharmacist intervention in reducing and preventing prescribing errors of investigational drugs for cancer patients. Materials and methods A retrospective study was conducted during two periods: a baseline period from December 2015 to June 2016 and an intervention period from July 2016 to February 2017. The investigational drug service (IDS) pharmacists performed active interventions during the intervention period. Results Among 12,387 investigational drug orders, 395 (6.1%) prescribing errors were detected in 6477 orders at the baseline period, and 278 errors (4.7%) were detected in 5,910 orders at the intervention period. To identify factors that affect prescribing errors, three models were constructed for the multivariate analysis. Among factors affecting prescribing errors, sponsor initiated trial (SIT) was the strongest factor (AOR: 4.16, 95% CI: 3.31-5.23). Pharmacist intervention reduced prescribing errors by at least 25% in all constructed models after adjusting for confounding variables. Prescribing errors were 1.3 times higher when dealing with intravenous medications than when dealing with oral medications. There were 60% fewer prescribing errors in the blinded study than in the open study. SIT and multi-center/multi-nation studies had 4.2 and 2.4 times more frequent prescribing errors than in investigator-initiated trials (IIT) and single-center/single-nation studies, respectively. Fewer errors occurred in phase 2 and trials covering both phase 1 and phase 2 (phase 1/2) than in phase 3 trials. Conclusions The IDS pharmacist intervention in cancer clinical trials was associated with significant reductions in prescribing errors and may lead to increased medication safety.
DOI
10.1177/1078155219834723
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약학대학 > 약학과 > Journal papers
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