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Cigarette smoke inhalation aggravates diabetic kidney injury in rats

Title
Cigarette smoke inhalation aggravates diabetic kidney injury in rats
Authors
Jiang, SonglingQuan, Do VanSung, Jae HyuckLee, Moo-YeolHa, Hunjoo
Ewha Authors
하헌주
SCOPUS Author ID
하헌주scopus
Issue Date
2019
Journal Title
TOXICOLOGY RESEARCH
ISSN
2045-452XJCR Link

2045-4538JCR Link
Citation
TOXICOLOGY RESEARCH vol. 8, no. 6, pp. 964 - 971
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. Epidemiological studies have demonstrated that cigarette smoke or nicotine is a risk factor for the progression of chronic kidney injury. The present study analyzed the kidney toxicity of cigarette smoke in experimental rats with DKD. Experimental diabetes was induced in 7-week-old Sprague-Dawley rats by a single intraperitoneal injection of streptozotocin (60 mg kg(-1)). Four weeks after the induction of diabetes, rats were exposed to cigarette smoke (200 mu g L-1), 4 h daily, and 5 days per week for 4 weeks. Cigarette smoke did not affect the levels of plasma glucose, hemoglobin A1c, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol or non-esterified fatty acids in both control and diabetic rats under the experimental conditions. Cigarette smoke, however, significantly increased diabetes-induced glomerular hypertrophy and urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) excretion, suggesting exacerbation of diabetic kidney injury. Cigarette smoke promoted macrophage infiltration and fibrosis in the diabetic kidney. As expected, cigarette smoke increased oxidative stress in both control and diabetic rats. These data demonstrated that four weeks of exposure to cigarette smoke aggravated the progression of DKD in rats.
DOI
10.1039/c9tx00201d
Appears in Collections:
약학대학 > 약학과 > Journal papers
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