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Azulene-Derived Fluorescent Probe for Bioimaging: Detection of Reactive Oxygen and Nitrogen Species by Two-Photon Microscopy

Title
Azulene-Derived Fluorescent Probe for Bioimaging: Detection of Reactive Oxygen and Nitrogen Species by Two-Photon Microscopy
Authors
Murfin, Lloyd C.Weber, MariaPark, Sang JunKim, Won TaeLopez-Alled, Carlos M.McMullin, Claire L.Pradaux-Caggiano, FabienneLyall, Catherine L.Kociok-Kohn, GabrieleWenk, JannisBull, Steven D.Yoon, JuyoungKim, Hwan MyungJames, Tony D.Lewis, Simon E.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2019
Journal Title
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN
0002-7863JCR Link

1520-5126JCR Link
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY vol. 141, no. 49, pp. 19389 - 19396
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Two-photon fluorescence microscopy has become an indispensable technique for cellular imaging. Whereas most two-photon fluorescent probes rely on well-known fluorophores, here we report a new fluorophore for bioimaging, namely azulene. A chemodosimeter, comprising a boronate ester receptor motif conjugated to an appropriately substituted azulene, is shown to be an effective two-photon fluorescent probe for reactive oxygen species, showing good cell penetration, high selectivity for peroxynitrite, no cytotoxicity, and excellent photostability.
DOI
10.1021/jacs.9b09813
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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