Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.contributor.author | 정우진 | * |
dc.contributor.author | 고려진 | * |
dc.date.accessioned | 2019-12-03T16:30:28Z | - |
dc.date.available | 2019-12-03T16:30:28Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0022-1767 | * |
dc.identifier.issn | 1550-6606 | * |
dc.identifier.other | OAK-26164 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252312 | - |
dc.description.abstract | The protein tyrosine kinase Src regulates the synthesis of TLR3-mediated IFN-beta via the TBK1-IFN regulatory factor 3 axis. However, the molecular mechanisms regulating Src activity in TLR3 signaling remain unclear. In this study, we report that GSK3 beta regulates Src phosphorylation via TNFR-associated factor 2 (TRAF2)-mediated Src ubiquitination. GSK3 beta deficiency in mouse embryonic fibroblasts significantly reduces polyinosinic:polycytidylic acid-induced IFN-beta and IFN-stimulated gene expression, which is caused by diminished phosphorylation of Src at tyrosine 416. Src undergoes polyinosinic:polycytidylic acid-dependent lysine 63 chain ubiquitination, and TRAF2 is a direct E3 ligase for Src. Our study reveals novel mechanisms underlying TLR3-mediated antiviral responses mediated via the GSK3 beta-TRAF2-Src axis. | * |
dc.language | English | * |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | * |
dc.title | Glycogen Synthase Kinase 3 beta Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 203 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2990 | * |
dc.relation.lastpage | 2999 | * |
dc.relation.journaltitle | JOURNAL OF IMMUNOLOGY | * |
dc.identifier.doi | 10.4049/jimmunol.1900685 | * |
dc.identifier.wosid | WOS:000497950400022 | * |
dc.identifier.scopusid | 2-s2.0-85075223243 | * |
dc.author.google | Ko, Ryeojin | * |
dc.author.google | Park, Hana | * |
dc.author.google | Lee, Nawon | * |
dc.author.google | Seo, Jeongin | * |
dc.author.google | Jeong, Woojin | * |
dc.author.google | Lee, Soo Young | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.contributor.scopusid | 정우진(35914322500) | * |
dc.contributor.scopusid | 고려진(54414431700) | * |
dc.date.modifydate | 20240415140424 | * |