Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황금숙 | * |
dc.date.accessioned | 2019-12-03T16:30:18Z | - |
dc.date.available | 2019-12-03T16:30:18Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1422-0067 | * |
dc.identifier.other | OAK-26061 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252281 | - |
dc.description.abstract | EPA, an omega-3 polyunsaturated fatty acid, exerts beneficial effects on human health. However, the molecular mechanisms underlying EPA function are poorly understood. The object was to illuminate molecular mechanism underlying EPA's role. Here, H-1-NMR-based metabolic analysis showed enhanced branched-chain amino acids (BCAAs) and lactate following EPA treatment in skeletal muscle cells. EPA regulated mitochondrial oxygen consumption rate. Furthermore, EPA induced calcium/calmodulin-dependent protein kinase kinase (CaMKK) through the generation of intracellular calcium. This induced the phosphorylation of AMP-activated protein kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) that led to glucose uptake, and the translocation of glucose transporter type 4 (GLUT4) in muscles. In conclusion, EPA exerts benign effects on glucose through the activation of AMPK-p38 MAPK signaling pathways in skeletal muscles. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | AMPK | * |
dc.subject | EPA | * |
dc.subject | GLUT4 | * |
dc.subject | oxygen consumption | * |
dc.title | Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway | * |
dc.type | Article | * |
dc.relation.issue | 19 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | * |
dc.identifier.doi | 10.3390/ijms20194751 | * |
dc.identifier.wosid | WOS:000494798300092 | * |
dc.author.google | Kim, Nami | * |
dc.author.google | Kang, Mi Sun | * |
dc.author.google | Nam, Miso | * |
dc.author.google | Kim, Shin Ae | * |
dc.author.google | Hwang, Geum-Sook | * |
dc.author.google | Kim, Hyeon Soo | * |
dc.contributor.scopusid | 황금숙(7202676099) | * |
dc.date.modifydate | 20240222154747 | * |