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Microbial production of O-methylated flavanones from methylated phenylpropanoic acids in engineered Escherichia coli

Title
Microbial production of O-methylated flavanones from methylated phenylpropanoic acids in engineered Escherichia coli
Authors
Cui, HeqingSong, Myoung ChongLee, Ji YoungYoon, Yeo Joon
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2019
Journal Title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN
1367-5435JCR Link

1476-5535JCR Link
Citation
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY vol. 46, no. 12, pp. 1707 - 1713
Keywords
Methylated flavanoneMicrobial productionHomoeriodictyolPhenylpropanoic acidEscherichia coli
Publisher
SPRINGER HEIDELBERG
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Methylated flavonoids possess improved bioactivities compared to their unmethylated counterparts. In this study, for the efficient production of O-methylated flavonoids from simple methylated phenylpropanoic acids, a recombinant Escherichia coli strain expressing 4-coumarate:coenzyme A ligase (4CL) from Oryza sativa and chalcone synthase (CHS) from Hordeum vulgare was constructed; this strain produced significant amount of homoeriodictyol (similar to 52 mg/L) as well as a few amount of hesperetin (0.4 mg/L), respectively, from ferulic acid and 4-methylcaffeic acid. This demonstrates, for the first time, that the scarce but valuable methylated flavanones can be successfully produced from methylated phenylpropanoic acids in a microbial host via an artificial biosynthetic pathway consisting of 4CL and CHS that can accept O-methylated precursors.
DOI
10.1007/s10295-019-02239-6
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자연과학대학 > 화학·나노과학전공 > Journal papers
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