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Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels

Title
Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels
Authors
Chung, Jun-moNoh, Jihyun
Ewha Authors
정준모
SCOPUS Author ID
정준모scopus
Issue Date
2019
Journal Title
EXPERIMENTAL NEUROBIOLOGY
ISSN
1226-2560JCR Link

2093-8144JCR Link
Citation
EXPERIMENTAL NEUROBIOLOGY vol. 28, no. 5, pp. 578 - 592
Keywords
Calcium-activated non-selective cationDopamine systemElectrophysiologyPatch clamp recordingSpike frequencyRat
Publisher
KOREAN SOC BRAIN &

NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state when neurons were intracellularly dialyzed with EGTA but attenuated the neuronal activity when BAPTA was used as an intracellular calcium buffer. This suggests that neuronal excitability can be modulated by zinc, depending on the internal calcium buffering capacity In this study we elucidated the mechanisms of zinc-mediated alterations in neuronal excitability and determined the effect of calcium-related channels cm zinc-mediated alterations in excitability The zinc-induced augmentation of firing activity was mediated via the inhibition of small-conductance calcium-activated potassium (SK) channels with not only the contribution of voltage-gated L-type calcium channels (VGCCs) and ryanodine receptors (Ry Rs), but also through the activation of VGCCs via melastatin-like transient receptor potential channels. We suggest that zinc modulates the dopaminergic neuronal activity by regulating not only SK channels as calcium sensors, but also VGCCs or RyRs as calcium sources. Our results suggest that the cytosolic calcium-buffering capacity can tightly regulate zinc-induced neuronal firing patterns and that local calcium-signaling domains can determine the physiological and pathological state of synaptic activity in the dopaminergic system.
DOI
10.5607/en.2019.28.5.578
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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