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Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia

Title
Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia
Authors
Kwon, Youngjoo
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2019
Journal Title
FOOD SCIENCE AND BIOTECHNOLOGY
ISSN
1226-7708JCR Link

2092-6456JCR Link
Citation
FOOD SCIENCE AND BIOTECHNOLOGY vol. 28, no. 6, pp. 1599 - 1606
Keywords
Benign prostatic hyperplasiaFatty acidsPhytosterolSaw palmetto extractStandardized formula
Publisher
KOREAN SOCIETY FOOD SCIENCE &

TECHNOLOGY-KOSFOST
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Review
Abstract
Benign prostatic hyperplasia (BPH) is a noncancerous growth of the prostate. BPH commonly occurs in elderly men. Lower urinary tract symptoms (LUTS) secondary to BPH (LUTS/BPH) have significant impacts on their health. Saw palmetto (Serenoa repens) extract (SPE) has been evaluated for its effectiveness in improvement of LUTS/BPH at preclinical and clinical levels. Potential mechanisms of actions include anti-androgenic, pro-apoptotic, and anti-inflammatory effects. However, SPE efficacy was inconsistent, at least partly due to a lack of a standardized SPE formula. A hexane extract (free fatty acids, > 80%) provided more consistent results. Free fatty acids (lauric acid) were effective in inhibition of 5 alpha-reductase, and phytosterol (beta-sitosterol) reduced prostatic inflammation. Multiple actions derived from different constituents may contribute to SPE efficacy. Evaluation of the clinical relevance of these bioactive components is required for standardization of SPE, thereby enabling consistent efficacy and recommendations for the use in the prevention and treatment of BPH.
DOI
10.1007/s10068-019-00605-9
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
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