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Visible Light-Induced Aromatic Difluoroalkylation

Title
Visible Light-Induced Aromatic Difluoroalkylation
Authors
Jung, JaehunKim, EunjinYou, YoungminCho, Eun Jin
Ewha Authors
유영민
SCOPUS Author ID
유영민scopus
Issue Date
2014
Journal Title
ADVANCED SYNTHESIS & CATALYSIS
ISSN
1615-4150JCR Link

1615-4169JCR Link
Citation
ADVANCED SYNTHESIS & CATALYSIS vol. 356, no. 13, pp. 2741 - 2748
Keywords
aromaticsdifluoroalkylationheteroaromaticsiridiumvisible light
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2-bromo-2,2-difluoroacetate (BrCF2CO2Et) in the presence of the triscyclometalated Ir complex fac-[Ir(ppy)(3)] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF2CO2Et moiety can be converted to a variety of other CF2-containing aromatics, demonstrating the synthetic utility of the present method.
DOI
10.1002/adsc.201400542
Appears in Collections:
엘텍공과대학 > 화학신소재공학전공 > Journal papers
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