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Visible Light-Induced Aromatic Difluoroalkylation
- Title
- Visible Light-Induced Aromatic Difluoroalkylation
- Authors
- Jung, Jaehun; Kim, Eunjin; You, Youngmin; Cho, Eun Jin
- Ewha Authors
- 유영민
- SCOPUS Author ID
- 유영민
- Issue Date
- 2014
- Journal Title
- ADVANCED SYNTHESIS & CATALYSIS
- ISSN
- 1615-4150
1615-4169
- Citation
- ADVANCED SYNTHESIS & CATALYSIS vol. 356, no. 13, pp. 2741 - 2748
- Keywords
- aromatics; difluoroalkylation; heteroaromatics; iridium; visible light
- Publisher
- WILEY-V C H VERLAG GMBH
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2-bromo-2,2-difluoroacetate (BrCF2CO2Et) in the presence of the triscyclometalated Ir complex fac-[Ir(ppy)(3)] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF2CO2Et moiety can be converted to a variety of other CF2-containing aromatics, demonstrating the synthetic utility of the present method.
- DOI
- 10.1002/adsc.201400542
- Appears in Collections:
- 공과대학 > 화공신소재공학과 > Journal papers
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