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DECREASED CIRCULATING KLOTHO LEVELS IN PATIENTS UNDERGOING DIALYSIS AND RELATIONSHIP TO OXIDATIVE STRESS AND INFLAMMATION

Title
DECREASED CIRCULATING KLOTHO LEVELS IN PATIENTS UNDERGOING DIALYSIS AND RELATIONSHIP TO OXIDATIVE STRESS AND INFLAMMATION
Authors
Oh, Hyung JungNam, Bo YoungLee, Mi JungKim, Chan HoKoo, Hyang MoDoh, Fa MeeHan, Jae HyunKim, Eun JinHan, Ji SukPark, Jung TakYoo, Tae-HyunKang, Shin-WookHan, Dae-SukHan, Seung Hyeok
Ewha Authors
오형중
SCOPUS Author ID
오형중scopus
Issue Date
2015
Journal Title
PERITONEAL DIALYSIS INTERNATIONAL
ISSN
0896-8608JCR Link
Citation
PERITONEAL DIALYSIS INTERNATIONAL vol. 35, no. 1, pp. 43 - 51
Keywords
ESRDinflammationklothooxidative stress
Publisher
MULTIMED INC
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Introduction: It has been reported that klotho deficiency is associated with oxidative stress and inflammation in experimental kidney disease models. Patients with end-stage renal disease (ESRD) are particularly characterized by increased oxidative stress and inflammation. However, little is known about the relationship between these features and klotho in patients with ESRD. Methods: We conducted a single-center, cross-sectional study of 78 patients receiving peritoneal dialysis (PD). Serum concentrations of klotho, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and 8-isoprostane were measured by enzyme-linked immunosorbent assay. To define factors independently associated with klotho, we determined Spearman's correlation coefficients for between co-variates and conducted multiple linear regression analyses. Results: Patients were classified by median concentration of klotho. In patients with klotho levels > 329.6 pg/mL, serum 8-isoprostane and IL-6 levels were significantly higher than in those with klotho levels < 329.6 pg/mL. In correlation analyses, log 8-isoprostane (gamma = -0.310, p = 0.006) and log IL-6 (gamma = -0.343, p = 0.002) were inversely correlated with log klotho. After adjustment for age, gender, mean arterial pressure, log intact parathyroid hormone, and log IL-6, log 8-isoprostane was independently associated with log klotho (beta = -0.158, p = 0.040). However, the significant relationship between klotho and IL-6 was not seen in an adjusted model. Conclusions: This study showed that circulating klotho levels were significantly associated with 8-isoprostane -levels in patients undergoing PD, suggesting a potential link between klotho deficiency and enhanced oxidative stress in ESRD patients.
DOI
10.3747/pdi.2013.00150
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의료원 > 의료원 > Journal papers
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