Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오형중 | - |
dc.date.accessioned | 2019-11-19T16:31:14Z | - |
dc.date.available | 2019-11-19T16:31:14Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0896-8608 | - |
dc.identifier.other | OAK-25742 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252125 | - |
dc.description.abstract | Introduction: It has been reported that klotho deficiency is associated with oxidative stress and inflammation in experimental kidney disease models. Patients with end-stage renal disease (ESRD) are particularly characterized by increased oxidative stress and inflammation. However, little is known about the relationship between these features and klotho in patients with ESRD. Methods: We conducted a single-center, cross-sectional study of 78 patients receiving peritoneal dialysis (PD). Serum concentrations of klotho, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and 8-isoprostane were measured by enzyme-linked immunosorbent assay. To define factors independently associated with klotho, we determined Spearman's correlation coefficients for between co-variates and conducted multiple linear regression analyses. Results: Patients were classified by median concentration of klotho. In patients with klotho levels > 329.6 pg/mL, serum 8-isoprostane and IL-6 levels were significantly higher than in those with klotho levels < 329.6 pg/mL. In correlation analyses, log 8-isoprostane (gamma = -0.310, p = 0.006) and log IL-6 (gamma = -0.343, p = 0.002) were inversely correlated with log klotho. After adjustment for age, gender, mean arterial pressure, log intact parathyroid hormone, and log IL-6, log 8-isoprostane was independently associated with log klotho (beta = -0.158, p = 0.040). However, the significant relationship between klotho and IL-6 was not seen in an adjusted model. Conclusions: This study showed that circulating klotho levels were significantly associated with 8-isoprostane -levels in patients undergoing PD, suggesting a potential link between klotho deficiency and enhanced oxidative stress in ESRD patients. | - |
dc.language | English | - |
dc.publisher | MULTIMED INC | - |
dc.subject | ESRD | - |
dc.subject | inflammation | - |
dc.subject | klotho | - |
dc.subject | oxidative stress | - |
dc.title | DECREASED CIRCULATING KLOTHO LEVELS IN PATIENTS UNDERGOING DIALYSIS AND RELATIONSHIP TO OXIDATIVE STRESS AND INFLAMMATION | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 35 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 43 | - |
dc.relation.lastpage | 51 | - |
dc.relation.journaltitle | PERITONEAL DIALYSIS INTERNATIONAL | - |
dc.identifier.doi | 10.3747/pdi.2013.00150 | - |
dc.identifier.wosid | WOS:000349987600009 | - |
dc.author.google | Oh, Hyung Jung | - |
dc.author.google | Nam, Bo Young | - |
dc.author.google | Lee, Mi Jung | - |
dc.author.google | Kim, Chan Ho | - |
dc.author.google | Koo, Hyang Mo | - |
dc.author.google | Doh, Fa Mee | - |
dc.author.google | Han, Jae Hyun | - |
dc.author.google | Kim, Eun Jin | - |
dc.author.google | Han, Ji Suk | - |
dc.author.google | Park, Jung Tak | - |
dc.author.google | Yoo, Tae-Hyun | - |
dc.author.google | Kang, Shin-Wook | - |
dc.author.google | Han, Dae-Suk | - |
dc.author.google | Han, Seung Hyeok | - |
dc.contributor.scopusid | 오형중(57191419598) | - |
dc.date.modifydate | 20210914114714 | - |