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Small Molecule Detection in Saliva Facilitates Portable Tests of Marijuana Abuse

Title
Small Molecule Detection in Saliva Facilitates Portable Tests of Marijuana Abuse
Authors
Lee, Jung-RokChoi, JoohongShultz, Tyler O.Wang, Shan X.
Ewha Authors
이정록
Issue Date
2016
Journal Title
ANALYTICAL CHEMISTRY
ISSN
0003-2700JCR Link

1520-6882JCR Link
Citation
ANALYTICAL CHEMISTRY vol. 88, no. 15, pp. 7457 - 7461
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
As medical and recreational use of cannabis, or marijuana, becomes more prevalent, law enforcement needs a tool to evaluate whether drivers are operating vehicles under the influence of cannabis, specifically the psychoactive substance, tetrahydrocannabinol (THC). However, the cutoff concentration of THC that causes impairment is still controversial, and current on-site screening tools are not sensitive enough to detect trace amounts of THC in oral fluids. Here we present a novel sensing platform that employs giant magnetoresistive (GMR) biosensors integrated with a portable reader system and smartphone to detect THC in saliva using competitive assays. With a simple saliva collection scheme, we have optimized the assay to measure THC in the range from 0 to 50 ng/mL, covering most cutoff values proposed in previous studies. This work facilitates on-site screening for THC and shows potential for testing of other small molecule drugs and analytes in point-of-care (POC) settings.
DOI
10.1021/acs.analchem.6b01688
Appears in Collections:
엘텍공과대학 > 휴먼기계바이오공학부 > Journal papers
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