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The Effects of Oral Cryotherapy on Oral Mucositis, Reactive Oxygen Series, Inflammatory Cytokines, and Oral Comfort in Gynecologic Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial

Title
The Effects of Oral Cryotherapy on Oral Mucositis, Reactive Oxygen Series, Inflammatory Cytokines, and Oral Comfort in Gynecologic Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial
Authors
Shin, NayeonKang, Younhee
Ewha Authors
강윤희
SCOPUS Author ID
강윤희scopus
Issue Date
2019
Journal Title
JOURNAL OF KOREAN ACADEMY OF NURSING
ISSN
2005-3673JCR Link

2093-758XJCR Link
Citation
JOURNAL OF KOREAN ACADEMY OF NURSING vol. 49, no. 2, pp. 149 - 160
Keywords
CytokinesCryotherapyDrug TherapyMucositis
Publisher
KOREAN SOC NURSING SCIENCE
Indexed
SCIE; SSCI; SCOPUS; KCI WOS
Document Type
Article
Abstract
Purpose: The purpose of this study was to examine the effects of oral cryotherapy on oral mucositis, reactive oxygen series, inflammatory cytokines, and oral comfort in patients undergoing chemotherapy for gynecologic cancers. Methods: Participants were randomly assigned to the experimental group (n=25, receiving oral cryotherapy during chemotherapy) and the control group (n=25, receiving the usual care consisting of 0.9% normal saline gargles three times before meals). Oral mucositis was assessed using the oral assessment guide, while oral comfort was assessed using the oral perception guide. Reactive oxygen series was measured as total oxidant stress, and the level of two inflammatory markers, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-(alpha)), were examined. The data were analyzed using t-test, chi-square test, Fisher's exact test, Mann-Whitney U-test, and repeated measures analysis of variance. Results: There was a significant difference in the oral mucositis score, reactive oxygen series score, TNF-(alpha), level, and oral comfort score between the two groups, and there were significant changes over time and in the group-by-time interactions. There was a significant difference in the IL-6 score between the two groups, but there were no significant changes over time or in the group-by-time interactions. Conclusion: The study results revealed that oral cryotherapy was more effective than the usual care regime of normal saline gargles for reducing oral mucositis, reactive oxygen series, and inflammatory cytokines and for improving oral comfort in gynecologic cancer patients undergoing chemotherapy.
DOI
10.4040/jkan.2019.49.2.149
Appears in Collections:
간호대학 > 간호학전공 > Journal papers
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