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Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation
- Title
- Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation
- Authors
- Kang, Unwoo; Han, Ah-Reum; So, Yangkang; Jin, Chang Hyun; Ryu, Seung Mok; Lee, Dongho; Seo, Eun Kyoung
- Ewha Authors
- 서은경
- SCOPUS Author ID
- 서은경
- Issue Date
- 2019
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- ISSN
- 0163-3864
1520-6025
- Citation
- JOURNAL OF NATURAL PRODUCTS vol. 82, no. 9, pp. 2601 - 2607
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Five new furanocoumarins, dahuribirin H (1), dahuribirin I (2), (2'S)-(+)-5-(2'-hydroxy-3'-methylbut-3'enyloxy)-8-(3 ''-methylbut-2 ''-enyloxy)psoralen (3), (2'R)(+)-5-(2',3'-epoxy-3'-methylbutoxy)-8-(3"-methylbut-2 ''- enyloxy)psoralen (4), and 5-methoxy-8((Z)-4'-(3 ''-methylbutanoate)-3'-methylbut-2'-enyloxy)psoralen (5), along with 15 known compounds (6-20), were isolated from the roots of Angelica dahurica. The structures of the new compounds were elucidated by spectroscopic analysis, along with electronic circular dichroism calculations and Mosher ester analysis. Compounds 3, 4, 11, 13, and 16 reduced H2O2-induced cell death in HepG2 cells and attenuated reactive oxygen species (ROS) formation without showing cytotoxicity, suggesting that these compounds might have cytoprotective effects against H2O2-induced oxidative damage via ROS scavenging activities.
- DOI
- 10.1021/acs.patprod.9b00547
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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