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Differential effects of typical Korean versus american-style diets on gut microbial composition and metabolic profile in healthy overweight koreans: A randomized crossover trial
- Title
- Differential effects of typical Korean versus american-style diets on gut microbial composition and metabolic profile in healthy overweight koreans: A randomized crossover trial
- Authors
- Shin J.-H.; Jung S.; Kim S.-A.; Kang M.-S.; Kim M.-S.; Joung H.; Hwang G.-S.; Shin D.-M.
- Ewha Authors
- 황금숙
- SCOPUS Author ID
- 황금숙
- Issue Date
- 2019
- Journal Title
- Nutrients
- ISSN
- 2072-6643
- Citation
- Nutrients vol. 11, no. 10
- Keywords
- American diet; Enterotype; Gut microbiota; Korean diet; Metabolomics; Randomized crossover trial
- Publisher
- MDPI AG
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The Westernized diet has been associated with the pathogenesis of metabolic diseases, whereas a Korean diet has been reported to exert beneficial effects on health in several studies. However, the effects of Western and Korean diets on the gut microbiome and host metabolome are unclear. To examine the diet-specific effects on microbiome and metabolome, we conducted a randomized crossover clinical trial of typical Korean diet (TKD), typical American diet (TAD), and recommended American diet (RAD). The trial involved a 4-week consumption of an experimental diet followed by a 2-week interval before diet crossover. 16S rRNA sequencing analysis identified 16, 10, and 14 differential bacteria genera specific to TKD, RAD, and TAD, respectively. The Firmucutes-Bacteroidetes ratio was increased by TKD. Nuclear magnetic resonance metabolome profiling revealed that TKD enriched branched chain amino acid metabolism, whereas ketone body metabolism was evident in RAD and TAD. Microbiome and metabolome responses to the experimental diets varied with individual enterotypes. These findings provide evidence that the gut microbiome and host metabolome rapidly respond to different cultural diets. The findings will inform clarification of the diet-related communication networks of the gut microbiome and host metabolome in humans. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/nu11102450
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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