DSpace at EWHA: A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform

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DC Field	Value	Language
dc.contributor.author	권영주	*
dc.date.accessioned	2019-10-29T16:30:23Z	-
dc.date.available	2019-10-29T16:30:23Z	-
dc.date.issued	2019	*
dc.identifier.issn	1359-7345	*
dc.identifier.issn	1364-548X	*
dc.identifier.other	OAK-25561	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/251635	-
dc.description.abstract	5-Hydroxy-2-phenyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one (compound 52) was found as a DNA non-intercalative topo II specific catalytic inhibitor by targeting its ATP-binding domain. Showing changes in interaction with Mg2+, it exhibited highly selective properties against the alpha -isoform with less toxicity, unlike other topo II poisons, such as etoposide.	*
dc.language	English	*
dc.publisher	ROYAL SOC CHEMISTRY	*
dc.title	A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform	*
dc.type	Article	*
dc.relation.issue	85	*
dc.relation.volume	55	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	12857	*
dc.relation.lastpage	12860	*
dc.relation.journaltitle	CHEMICAL COMMUNICATIONS	*
dc.identifier.doi	10.1039/c9cc05524j	*
dc.identifier.wosid	WOS:000495648400022	*
dc.identifier.scopusid	2-s2.0-85073665101	*
dc.author.google	Park, Seojeong	*
dc.author.google	Hwang, Soo-Yeon	*
dc.author.google	Shin, Jaeho	*
dc.author.google	Jo, Hyunji	*
dc.author.google	Na, Younghwa	*
dc.author.google	Kwon, Youngjoo	*
dc.contributor.scopusid	권영주(12446435600)	*
dc.date.modifydate	20240422124907	*