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Analysis of microarray right-censored data through fused sliced inverse regression

Title
Analysis of microarray right-censored data through fused sliced inverse regression
Authors
Yoo J.K.
Ewha Authors
유재근
SCOPUS Author ID
유재근scopus
Issue Date
2019
Journal Title
Scientific Reports
ISSN
2045-2322JCR Link
Citation
Scientific Reports vol. 9, no. 1
Publisher
Nature Publishing Group
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Sufficient dimension reduction (SDR) for a regression pursue a replacement of the original p-dimensional predictors with its lower-dimensional linear projection. The so-called sliced inverse regression (SIR; [5]) arguably has the longest history in SDR methodologies, but it is still one of the most popular one. The SIR is known to be easily affected by the number of slices, which is one of its critical deficits. Recently, a fused approach for SIR is proposed to relieve this weakness, which fuses the kernel matrices computed by the SIR application from various numbers of slices. In the paper, the fused SIR is applied to a large-p-small n regression of a high-dimensional microarray right-censored data to show its practical advantage over usual SIR application. Through model validation, it is confirmed that the fused SIR outperforms the SIR with any number of slices under consideration. © 2019, The Author(s).
DOI
10.1038/s41598-019-51441-0
Appears in Collections:
자연과학대학 > 통계학전공 > Journal papers
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