DSpace at EWHA: Correlation study between A(3) adenosine receptor binding affinity and anti-renal interstitial fibrosis activity of truncated adenosine derivatives

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DC Field	Value	Language
dc.contributor.author	하헌주	*
dc.date.accessioned	2019-10-02T01:59:58Z	-
dc.date.available	2019-10-02T01:59:58Z	-
dc.date.issued	2019	*
dc.identifier.issn	0253-6269	*
dc.identifier.issn	1976-3786	*
dc.identifier.other	OAK-25333	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/251467	-
dc.description.abstract	Truncated 4 '-thionucleosides 1-4 and 4 '-oxonucleosides 5-8 as potent and selective A(3)AR antagonists were synthesized from d-mannose and d-erythronic acid gamma-lactone, respectively. These nucleosides were evaluated for their anti-fibrotic renoprotective activity in TGF-beta 1-treated murine proximal tubular (mProx) cells. Their antagonistic activities for A(3)AR were proportional to their inhibitory activities against TGF-beta 1-induced collagen I upregulation in mProx cells. This result suggests that the binding affinity of A(3)AR antagonists is closely correlated with their anti-fibrotic activity. Thus, A(3)AR antagonists might be novel therapeutic candidates for treating chronic kidney disease.	*
dc.language	English	*
dc.publisher	PHARMACEUTICAL SOC KOREA	*
dc.subject	A(3) adenosine receptor	*
dc.subject	Antagonist	*
dc.subject	Binding affinity	*
dc.subject	Truncated adenosine	*
dc.subject	Renal fibrosis	*
dc.title	Correlation study between A(3) adenosine receptor binding affinity and anti-renal interstitial fibrosis activity of truncated adenosine derivatives	*
dc.type	Article	*
dc.relation.issue	9	*
dc.relation.volume	42	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.index	KCI	*
dc.relation.startpage	773	*
dc.relation.lastpage	779	*
dc.relation.journaltitle	ARCHIVES OF PHARMACAL RESEARCH	*
dc.identifier.doi	10.1007/s12272-018-1079-2	*
dc.identifier.wosid	WOS:000483739200004	*
dc.identifier.scopusid	2-s2.0-85054181024	*
dc.author.google	Yu, Jinha	*
dc.author.google	Kim, Gyudong	*
dc.author.google	Jarhad, Dnyandev B.	*
dc.author.google	Lee, Hyuk Woo	*
dc.author.google	Lee, Jiyoun	*
dc.author.google	Park, Chong Woo	*
dc.author.google	Ha, Hunjoo	*
dc.author.google	Jeong, Lak Shin	*
dc.contributor.scopusid	하헌주(7202277106)	*
dc.date.modifydate	20240422113229	*