Total Synthesis of Hoiamide A Using an Evans-Tishchenko Reaction as a Key Step

Abstract

The first total synthesis of neurotoxic cyclodepsipeptide hoiamide A (1) has been accomplished. The synthesis features the use of an Evans-Tishchenko fragment coupling between a five-stereogenic-center-containing β-hydroxyketone and a chiral aldehyde derived from threonine. Copyright © 2019 American Chemical Society.