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Role of PI-RADS Version 2 for Prediction of Upgrading in Biopsy-Proven Prostate Cancer With Gleason Score 6
- Title
- Role of PI-RADS Version 2 for Prediction of Upgrading in Biopsy-Proven Prostate Cancer With Gleason Score 6
- Authors
- Song W.; Bang S.H.; Jeon H.G.; Jeong B.C.; Seo S.I.; Jeon S.S.; Choi H.Y.; Kim C.K.; Lee H.M.
- Ewha Authors
- 송완
- Issue Date
- 2018
- Journal Title
- Clinical Genitourinary Cancer
- ISSN
- 1558-7673
- Citation
- Clinical Genitourinary Cancer vol. 16, no. 4, pp. 281 - 287
- Keywords
- Magnetic resonance imaging; PI-RADSv2; Prostate cancer; Radical prostatectomy; Upgrading
- Publisher
- Elsevier Inc.
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We investigated the role of Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) for prediction of upgrading in patients with biopsy Gleason score 6 prostate cancers. After retrospective analysis of 443 patients, clinical parameters with PI-RADSv2 showed significantly higher accuracy for upgrading compared with clinical parameters alone. PI-RADSv2 might be used as a preoperative imaging tool to determine risk classification. Introduction: The objective of this study was to investigate the effect of Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) on prediction of postoperative Gleason score (GS) upgrading for patients with biopsy GS 6 prostate cancer. Patients and Methods: We retrospectively reviewed 443 patients who underwent magnetic resonance imaging (MRI) and radical prostatectomy for biopsy-proven GS 6 prostate cancer between January 2011 and December 2013. Preoperative clinical variables and pathologic GS were examined, and all MRI findings were assessed with PI-RADSv2. Receiver operating characteristic curves were used to compare predictive accuracies of multivariate logistic regression models with or without PI-RADSv2. Results: Of the total 443 patients, 297 (67.0%) experienced GS upgrading postoperatively. PI-RADSv2 scores 1 to 3 and 4 to 5 were identified in 157 (25.4%) and 286 (64.6%) patients, respectively, and the rate of GS upgrading was 54.1% and 74.1%, respectively (P <.001). In multivariate analysis, prostate-specific antigen density > 0.16 ng/mL2, number of positive cores ≥ 2, maximum percentage of cancer per core > 20, and PI-RADSv2 score 4 to 5 were independent predictors influencing GS upgrading (each P <.05). When predictive accuracies of multivariate models with or without PI-RADSv2 were compared, the model including PI-RADSv2 was shown to have significantly higher accuracy (area under the curve, 0.729 vs. 0.703; P =.041). Conclusion: Use of PI-RADSv2 is an independent predictor of postoperative GS upgrading and increases the predictive accuracy of GS upgrading. PI-RADSv2 might be used as a preoperative imaging tool to determine risk classification and to help counsel patients with regard to treatment decision and prognosis of disease. © 2018 Elsevier Inc.
- DOI
- 10.1016/j.clgc.2018.02.015
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
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